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Discussions integrated emerging findings from longitudinal cohorts, new molecular and neuroimaging approaches, expanding\n                    <jats:italic>post mortem<\/jats:italic>\n                    evidence, and evolving insights into exposure biology and genetic modifiers. Consensus themes emphasized the need for biomarkers that detect CTE\u2010specific tau proteoforms, integration of existing imaging and fluid markers into traumatic encephalopathy syndrome research criteria, and refinement of multimodal magnetic resonance imaging and blood\u2010based tools that capture early CTE pathology. The group underscored the importance of coordinated, longitudinal clinicopathological studies and collaborative research frameworks to validate candidate biomarkers and accelerate progress toward accurate diagnosis, disease monitoring, and therapeutic development for individuals at risk for or exhibiting signs of CTE.\n                  <\/jats:p>","DOI":"10.1002\/alz.71424","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T03:54:16Z","timestamp":1778644456000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Advancing biomarker development for chronic traumatic encephalopathy: Summary and recommendations from the 2025 Leon Thal Summit"],"prefix":"10.1002","volume":"22","author":[{"given":"Charles","family":"Bernick","sequence":"first","affiliation":[{"name":"Cleveland Clinic Lou Ruvo Center for Brain Health  Las Vegas Nevada USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brooke Conway","family":"Kleven","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics School of Public Health University of Nevada  Las Vegas Nevada USA"},{"name":"Department of Brain Health Kirk Kerkorian School of Medicine University of Nevada  Las Vegas Nevada USA"},{"name":"Chambers\u2010Grundy Center for Transformative Neuroscience Department of Brain Health Kirk Kerkorian School of Medicine University of Nevada  Las Vegas Nevada USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael L.","family":"Alosco","sequence":"additional","affiliation":[{"name":"Department of Neurology Boston University Chobanian &amp; 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