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In keeping with the known function of the LC, neuropsychological tests showed that LC integrity at baseline predicted changes in attention. Finally, we found that longitudinal LC degeneration correlated with memory decline in people with elevated neocortical amyloid burden.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Our findings underscore the importance of LC in AD pathogenesis. Longitudinal measurement of LC degeneration may help distinguish trajectories of age\u2010related cognitive decline and early AD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71427","type":"journal-article","created":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T14:24:38Z","timestamp":1777040678000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Locus coeruleus degeneration is associated with cortical tau deposition and cognitive decline in older adults at familial risk of Alzheimer's disease"],"prefix":"10.1002","volume":"22","author":[{"given":"Alfie","family":"Wearn","sequence":"first","affiliation":[{"name":"Montreal Neurological Institute, Department of Neurology and Neurosurgery McGill University Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate M.","family":"Onuska","sequence":"additional","affiliation":[{"name":"Schulich Medicine and Dentistry, Western University  London ON Canada"},{"name":"Robarts Research Institute Western University  London ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayley R. 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