{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T07:16:58Z","timestamp":1783322218788,"version":"3.54.6"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T00:00:00Z","timestamp":1777161600000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100006775","name":"GE Healthcare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006775","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016545","name":"Roche Diagnostics","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016545","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Quantitative evaluations of how recommendations influence clinical practice are limited. This study assessed changes in the diagnostic pathways after the 2020 Italian Intersocietal Consensus Recommendations (IICR) for biomarker\u2010based dementia diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Medical charts of new patients referred to three Italian memory clinics were reviewed for 2018 and 2019 (pre\u2010IICR) and 2022 and 2023 (post\u2010IICR). Sociodemographic and clinical data were extracted. Adherence to IICR was measured using an adherence index (AI, range 0\u20135). Deviations from recommended pathways were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      We analyzed 601 pathways in pre\u2010IICR and 434 in post\u2010IICR. Biomarker\u2010based diagnoses increased from 23% to 41% post\u2010IICR, with a significant redistribution of diagnostic categories and greater biomarker use. The AI increased modestly (2.09\u00a0\u00b1\u00a01.04 to 2.28\u00a0\u00b1\u00a01.04;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.04), driven by improved neuropsychological assessment and biomarker selection (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). Deviation analyses showed that adherence remained heterogeneous, with reduced biomarker use in older patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Diagnostic practices partially aligned with IICR, reflecting a progressive shift toward standardized, biologically informed dementia diagnosis in Italian expert centers.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71432","type":"journal-article","created":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T04:15:43Z","timestamp":1777263343000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The adherence of memory clinics to consensus recommendations for dementia diagnosis: A multicentric study in Italy"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3597-5097","authenticated-orcid":false,"given":"Cristina","family":"Festari","sequence":"first","affiliation":[{"name":"Laboratory of Alzheimer's Neuroimaging and Epidemiology IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Singh Solorzano","sequence":"additional","affiliation":[{"name":"Department of Pharmacological and Biomolecular Sciences University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Orini","sequence":"additional","affiliation":[{"name":"Cognitive Disorders and Dementia Rehabilitation Unit IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli  Brescia Italy"},{"name":"Department of Clinical and Experimental Sciences Universit\u00e0 degli Studi di Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleonora","family":"Castagna","sequence":"additional","affiliation":[{"name":"Department of Human Neurosciences Sapienza University of Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Cotta Ramusino","sequence":"additional","affiliation":[{"name":"Unit of Behavioral Neurology and Dementia Research Center (DRC) IRCCS Mondino Foundation  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizia","family":"D'Antonio","sequence":"additional","affiliation":[{"name":"Department of Human Neurosciences Sapienza University of Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adolfo","family":"Di Crosta","sequence":"additional","affiliation":[{"name":"Department of Psychology University G. d'Annunzio  Chieti\u2010Pescara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Mas\u00f2tino","sequence":"additional","affiliation":[{"name":"Department of Medicine and Aging Sciences University G. d'Annunzio  Chieti\u2010Pescara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Massa","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI) University of Genoa  Genoa Italy"},{"name":"IRCCS Azienda Ospedaliera Metropolitana  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Mazzonetto","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, and Padua Neuroscience Center University of Padova  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimiliano","family":"Panigutti","sequence":"additional","affiliation":[{"name":"Department of Human Neurosciences Sapienza University of Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noemi","family":"Rav\u00ec","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, and Padua Neuroscience Center University of Padova  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michela","family":"Pievani","sequence":"additional","affiliation":[{"name":"Laboratory of Alzheimer's Neuroimaging and Epidemiology IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Bonanni","sequence":"additional","affiliation":[{"name":"Department of Medicine and Aging Sciences University G. d'Annunzio  Chieti\u2010Pescara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Bruno","sequence":"additional","affiliation":[{"name":"Department of Human Neurosciences Sapienza University of Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annachiara","family":"Cagnin","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, and Padua Neuroscience Center University of Padova  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Gatta","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Sciences Universit\u00e0 degli Studi di Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni Battista","family":"Frisoni","sequence":"additional","affiliation":[{"name":"Division of Geriatrics and Rehabilitation, Memory Centre University Hospitals of Geneva  Geneva Switzerland"},{"name":"Laboratory of Neuroimaging of Aging (LANVIE) University of Geneva  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2024.3770"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13859"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000009323"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31821103e6"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr179"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573\u2010025\u201001165\u2010w"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2212948"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/J.1468\u20101331.2012.03784.X"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259\u2010020\u201004817\u20108"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13728"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(23)00447\u20107"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.14117"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010170284"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000223664"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.49.4.925"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380\u2010020\u20100721\u20109"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072\u2010024\u201007478\u20109"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/2156857X.2018.1542335"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00406\u2010022\u201001439\u2010z"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010024\u201001465\u20100"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2014.06.006"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072\u2010004\u20100356\u20107"}],"container-title":["Alzheimer's &amp; Dementia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.71432","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/alz.71432","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.71432","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T07:04:10Z","timestamp":1783321450000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz.71432"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1002\/alz.71432"],"URL":"https:\/\/doi.org\/10.1002\/alz.71432","archive":["Portico"],"relation":{},"ISSN":["1552-5260","1552-5279"],"issn-type":[{"value":"1552-5260","type":"print"},{"value":"1552-5279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"2026-01-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71432"}}