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Enhanced Hi\u2010C Capture Analysis (eHiCA) examined chromatin interactions using induced pluripotent stem cell (iPSC) \u2010derived cells from AD brain autopsy samples.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      LAVA identified a region shared between AD and stroke on chromosome 18q21.33(\n                      <jats:italic>\n                        r\n                        <jats:sub>g<\/jats:sub>\n                      <\/jats:italic>\n                      \u00a0=\u00a00.77,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a02.41\u00d710\n                      <jats:sup>\u22126<\/jats:sup>\n                      ). eHiCA demonstrated that the AD and stroke loci interact with regulatory elements in\n                      <jats:italic>PHLPP1<\/jats:italic>\n                      . Variants at\n                      <jats:italic>PHLPP1<\/jats:italic>\n                      were also associated with AD in an independent set of individuals of African ancestry (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a04.56 \u00d7 10\n                      <jats:sup>\u22125<\/jats:sup>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>\n                      This study identified a region on top of\n                      <jats:italic>PHLPP1<\/jats:italic>\n                      as a locus associated with both AD and stroke.\n                      <jats:italic>PHLPP1<\/jats:italic>\n                      inhibits protein kinase B, which contributes to both AD and stroke pathophysiology.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71433","type":"journal-article","created":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T15:12:32Z","timestamp":1777302752000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Genetic correlation analysis of Alzheimer's disease and stroke implicates\n                    <i>PHLPP1<\/i>\n                    as a shared locus in individuals of African ancestry"],"prefix":"10.1002","volume":"22","author":[{"given":"Nicholas R.","family":"Ray","sequence":"first","affiliation":[{"name":"Columbia University Irving Medical Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiji","family":"Kurup","sequence":"additional","affiliation":[{"name":"Columbia University Irving Medical Center  New York New York 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