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Modified Poisson regression with robust error variance was used to examine the associations of LE8 scores and genetic risk, as well as their joint associations, with cognitive impairment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Compared with the low LE8 score group, the high LE8 score group had a prevalence ratio (PR) of 0.65 (95% confidence interval [CI]: 0.56 to 0.76) for cognitive impairment. A joint association was observed between LE8 and genetic risk, with the highest PR of 1.19 (95% CI: 1.12 to 1.27) in the low LE8 and high\u2010genetic\u2010risk group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Optimal cardiovascular health was associated with lower cognitive impairment and attenuation of genetic risks among older adults in western China.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71437","type":"journal-article","created":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T03:00:16Z","timestamp":1779159616000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Life's Essential 8, genetic susceptibility, and risk of cognitive impairment: results from an elder population\u2010based cohort 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