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Studying CR in semantic variant primary progressive aphasia (svPPA) may clarify variability in disease progression and identify protective factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We examined whether education and occupational attainment\u2014two common CR proxies\u2014moderated relationships between gray matter brain volume and cognitive performance in 58 individuals with svPPA. Multiple linear regression models assessed baseline and longitudinal change across five semantic and non\u2010semantic tasks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Greater brain volume related to better cognitive performance across all tasks. However, CR moderated this relationship only for semantic tasks. At baseline, higher education\/occupation was linked to better semantic performance when brain volume was lower. Longitudinally, higher education\/occupation was associated with faster decline in semantic performance when brain volume was lower.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>CR influences language performance in svPPA, suggesting its effects are domain\u2010specific and aligned with the progression pattern of this syndrome.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71440","type":"journal-article","created":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T03:21:44Z","timestamp":1777864904000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cognitive reserve and longitudinal changes in brain and cognition in semantic variant primary progressive aphasia"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-6118-757X","authenticated-orcid":false,"given":"Lauren A.","family":"Grebe","sequence":"first","affiliation":[{"name":"Communication Sciences and Disorders St. John's University  Jamaica New York USA"},{"name":"Memory and Aging Center, Department of Neurology University of California, San Francisco  San Francisco California USA"},{"name":"Speech\u2010Language\u2010Hearing Sciences The Graduate Center, City University of New York  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brittany T.","family":"Morin","sequence":"additional","affiliation":[{"name":"Memory and Aging Center, Department of Neurology University of California, San Francisco  San Francisco California USA"},{"name":"Mission Bay Campus University of California, San Francisco  San Francisco California 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California, San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoe","family":"Ezzes","sequence":"additional","affiliation":[{"name":"Memory and Aging Center, Department of Neurology University of California, San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa D.","family":"Wauters","sequence":"additional","affiliation":[{"name":"Memory and Aging Center, Department of Neurology University of California, San Francisco  San Francisco California USA"},{"name":"Speech, Language, and Hearing Sciences University of Texas at Austin  Austin Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Luisa","family":"Mandelli","sequence":"additional","affiliation":[{"name":"Memory and Aging Center, Department of Neurology University of California, San Francisco  San Francisco California 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