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Data were retrospectively extracted from electronic health records.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>The median age was 73.2 years (52% female; 93% White). In total, 455 amyloid positron emission tomography (PET) scans, 505 cerebrospinal fluid tests, and 242 blood tests were performed. The number of biomarker tests increased seven\u2010fold over the past 4 years. The rate of positivity was \u224870% across modalities. Higher rates of biomarker positivity were associated with older age, female sex, and White race; lower rates were associated with hypertension and diabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Biomarker testing greatly increased following the approval of amyloid\u2010targeting treatments. The overall rate of biomarker positivity was high and varied by demographic factors and medical comorbidities.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71442","type":"journal-article","created":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T10:46:24Z","timestamp":1777891584000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Usage and positivity rates of Alzheimer's disease biomarkers in a memory clinic"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-6104-8012","authenticated-orcid":false,"given":"Anna","family":"Hofmann","sequence":"first","affiliation":[{"name":"Department of Neurology Washington University  St. Louis Missouri USA"},{"name":"Knight Alzheimer Disease Research Center Washington University  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Saef","sequence":"additional","affiliation":[{"name":"Department of Neurology Washington University  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William J. 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