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Disruption of these pathways may weaken homeostatic mechanisms and facilitate amyloid\u2011\u03b2 and tau buildup. This review considers lymphatic reconstruction as a potential therapeutic direction aimed at modestly improving clearance efficiency. We summarize current findings from pharmacological approaches targeting aquaporin\u20104 or vascular endothelial growth factor C signaling, non\u2010invasive methods such as photobiomodulation and focused ultrasound, and emerging surgical or lifestyle interventions designed to enhance drainage. Early clinical attempts, including deep cervical lymphovenous anastomosis (dCLVA), provide preliminary proof of concept but require careful validation. Progress in this field also depends on developing sensitive, non\u2010invasive imaging markers and defining appropriate intervention windows. 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