{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T06:00:11Z","timestamp":1785477611092,"version":"3.56.0"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T00:00:00Z","timestamp":1778371200000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100014392","name":"Avid Radiopharmaceuticals","doi-asserted-by":"publisher","award":["NCT02350634"],"award-info":[{"award-number":["NCT02350634"]}],"id":[{"id":"10.13039\/100014392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG070826"],"award-info":[{"award-number":["R01AG070826"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006312","name":"BrightFocus Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006312","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>\n                      Clinicopathological studies offer crucial interpretations of\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010flortaucipir (FTP) tau positron emission tomography (PET) signal but are limited by methods. We leveraged whole\u2010brain, quantitative immunohistochemical (IHC) Alzheimer's Disease (AD) tau density maps to comprehensively evaluate the FTP tracer.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We generated IHC maps for three AD\u2010tau antibodies\u2014AT8, AT100, and MC1\u2014using two human brains histologically staged at Braak IV and VI. FTP\u2010PET scans were acquired 6 and 10\u00a0weeks prior to death. Using region\u2010wise and voxelwise methods, we correlated FTP\u2010PET with IHC signals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Only AT8 (p\u2010tau Ser202\/Thr205; neuronal and neuritic tau pathology) showed a notable correlation with FTP standardized uptake value ratios (SUVRs)\u00a0in the Braak VI case (Spearman's rank correlation coefficient [r\n                      <jats:sub>s<\/jats:sub>\n                      ]\u00a0=\u00a00.461,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). FTP SUVRs failed to capture medial temporal lobe (MTL) tau burden, whereas neocortical regions showed lower IHC burden but more variability in FTP uptake.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Although FTP signals correlate well with AT8\u2010positive tau in the more advanced case, they underestimate the severity of MTL burden, potentially confounding assessments of tau\u2010targeted therapies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71453","type":"journal-article","created":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T03:16:08Z","timestamp":1778469368000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Correlation between in vivo\n                    <sup>18<\/sup>\n                    F\u2010flortaucipir PET and whole\u2010brain postmortem histological tau signals in Alzheimer's disease"],"prefix":"10.1002","volume":"22","author":[{"given":"Yishu","family":"Chao","sequence":"first","affiliation":[{"name":"Department of Neuroscience University of California, Berkeley  Berkeley California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuheng","family":"Chen","sequence":"additional","affiliation":[{"name":"Memory and Aging Center, Departments of Neurology and Pathology University of California  San Francisco California USA"},{"name":"Department of Neuroscience Mayo Clinic  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trevor A.","family":"Chadwick","sequence":"additional","affiliation":[{"name":"Department of Neuroscience University of California, Berkeley  Berkeley California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa M.","family":"Harrison","sequence":"additional","affiliation":[{"name":"Department of Neuroscience University of California, Berkeley  Berkeley California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Iaccarino","sequence":"additional","affiliation":[{"name":"Lilly Corporate Center Eli Lilly and Company  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helmut","family":"Heinsen","sequence":"additional","affiliation":[{"name":"Josef\u2010Schneider\u2010Strasse 11 University of W\u00fcrzburg  W\u00fcrzburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Ushizima","sequence":"additional","affiliation":[{"name":"Applied Mathematics and Computational Research Division Lawrence Berkeley National Laboratory  Berkeley California USA"},{"name":"Bakar Computational Health Sciences Institute University of California, San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duygu","family":"Tosun","sequence":"additional","affiliation":[{"name":"Department of Radiology and Biomedical Imaging University of California, San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William J.","family":"Jagust","sequence":"additional","affiliation":[{"name":"Department of Neuroscience University of California, Berkeley  Berkeley California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6809-0618","authenticated-orcid":false,"given":"Lea T.","family":"Grinberg","sequence":"additional","affiliation":[{"name":"Memory and Aging Center, Departments of Neurology and Pathology University of California  San Francisco California USA"},{"name":"Department of Neuroscience Mayo Clinic  Jacksonville Florida USA"},{"name":"LIM\u201022, Department of Pathology University of S\u00e3o Paulo  S\u00e3o Paulo S\u00e3o Paulo Brazil"},{"name":"Department of Laboratory Medicine and Pathology Mayo Clinic  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12694"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.02.018"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32205-4"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12937"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41583-018-0067-3"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.58.12.1791"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00308809"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-016-0315-6"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24517"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25406"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aau5732"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2019.1424"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2020.0528"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-024-02801-2"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.ado8076"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2019.09.079"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13550-020-00653-x"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2018.3692"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaa276"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2021.118790"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(95)11484-E"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12321"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1327.1998.2520542.x"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(00)00157-3"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.01.021"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dib.2017.10.024"},{"key":"e_1_2_10_28_1","first-page":"904","article-title":"Correction for partial volume effects in PET: principle and validation","volume":"39","author":"Rousset OG","year":"1998","journal-title":"J Nucl Med"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.118.224113"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2016.08.005"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.117.195248"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-170840"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2017-316409"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.123.265941"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-021-05401-4"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-025-02000-6"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.10.029"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-026-02983-x"}],"container-title":["Alzheimer's &amp; Dementia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.71453","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/alz.71453","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.71453","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T05:24:53Z","timestamp":1785475493000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz.71453"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":37,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1002\/alz.71453"],"URL":"https:\/\/doi.org\/10.1002\/alz.71453","archive":["Portico"],"relation":{},"ISSN":["1552-5260","1552-5279"],"issn-type":[{"value":"1552-5260","type":"print"},{"value":"1552-5279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"2026-01-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71453"}}