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Focusing on SCD+\/MNPD+ participants triples the positive predictive value of amyloid biomarker testing for the 5\u2010year prediction of MCI and reduces the required samples size for trials in preclinical AD to one fourth, compared to considering all cognitively normal participants regardless of subtle symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>SCD and MNPD offer a powerful approach for risk stratification in preclinical AD, which can improve clinical trial designs, risk counseling, and future case identifications for early treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71458","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T03:22:13Z","timestamp":1778728933000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Minor neuropsychological deficits and stage 2 of Alzheimer's disease"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-3812-023X","authenticated-orcid":false,"given":"Melina","family":"Stark","sequence":"first","affiliation":[{"name":"Department of Old Age Psychiatry and Cognitive Disorders University Hospital Bonn, University Bonn Bonn Germany"},{"name":"German Center for Neurodegenerative Diseases (DZNE) Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Wagner","sequence":"additional","affiliation":[{"name":"Department of Old Age Psychiatry and Cognitive Disorders University Hospital Bonn, University Bonn Bonn Germany"},{"name":"German Center for Neurodegenerative Diseases (DZNE) Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Kuhn","sequence":"additional","affiliation":[{"name":"Department of Old Age Psychiatry and Cognitive Disorders University Hospital Bonn, University Bonn Bonn Germany"},{"name":"German Center for Neurodegenerative Diseases (DZNE) Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Roeske","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE) Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger","family":"Amthauer","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Campus Virchow\u2010Klinikum Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Bartels","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy University Medical Center Goettingen University of Goettingen  Goettingen 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