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We investigated joint associations of 13 natural, social, and built\u2010environment exposures with gray matter volume (GMV) (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a01219), white matter fractional anisotropy (WM FA) (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a01102), and white matter hyperintensity volume (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a01210) using weighted quantile sum regression.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>A one\u2010decile increase in all harmful exposures was associated with lower GMV and WM FA; however, associations were null when adjusting for study site.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Examining the impact of many environmental factors simultaneously may provide insight into important modifiable risk factors for ADRD, capturing concomitant exposures as they are experienced.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71459","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T03:21:57Z","timestamp":1779247317000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mixtures of key components of the external exposome in association with MRI biomarkers of brain structure: Multi\u2010Ethnic Study of Atherosclerosis"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2058-0538","authenticated-orcid":false,"given":"Cameron J.","family":"Reimer","sequence":"first","affiliation":[{"name":"Department of Epidemiology Boston University School of Public Health  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tara E.","family":"Jenson","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Boston University School of Public Health  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yorghos","family":"Tripodis","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Boston University School of Public Health  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichiro","family":"Shiba","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Boston University School of Public Health  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"James","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences, Davis School of Medicine University of California  Davis California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kipruto","family":"Kirwa","sequence":"additional","affiliation":[{"name":"Department of Environmental Health Boston University School of Public Health  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan R.","family":"Heckbert","sequence":"additional","affiliation":[{"name":"Department of Epidemiology University of Washington  Seattle Washington USA"},{"name":"Cardiovascular Health Research Unit University of Washington School of Medicine and School of Public Health  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana A.","family":"Hirsch","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, Dornsife School of Public Health Drexel University  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilah","family":"Besser","sequence":"additional","affiliation":[{"name":"Department of Neurology, Comprehensive Center for Brain Health University of Miami Miller School of Medicine  Boca Raton Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Hughes","sequence":"additional","affiliation":[{"name":"Section of Gerontology and Geriatric Medicine, Department of Internal Medicine Wake Forest School of Medicine  Winston Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel D.","family":"Kaufman","sequence":"additional","affiliation":[{"name":"Department of Epidemiology University of Washington  Seattle Washington USA"},{"name":"Department of Environmental and Occupational Health Sciences University of Washington  Seattle Washington USA"},{"name":"Department of Medicine University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brent A.","family":"Coull","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Harvard T. 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