{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T18:09:40Z","timestamp":1788286180146,"version":"build-2803163510"},"reference-count":49,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T00:00:00Z","timestamp":1779062400000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Early detection of Alzheimer's disease (AD) is critical for timely intervention as disease\u2010modifying treatments emerge. Speech\u2010based digital biomarkers offer scalable options for remotely capturing speech\u2010derived functional changes associated with early cognitive decline, but validation across real\u2010world populations remains limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We evaluated the speech biomarker for cognition (SB\u2010C), an automated speech\u2010derived measure associated with cognitive status, in 736 participants across five European cohorts (Barcelona\u03b2eta Brain Research Center's Alzheimer's at\u2010risk cohort, European Prevention of Alzheimer's Dementia Scotland, Dementia Study of Cognitive and Biomarker Dynamics, Longitudinal Cognitive Impairment and Dementia Study, and Biomarkers for Identifying Neurodegenerative Disorders Early and Reliably [BioFINDER\u2010Primary Care]). Participants completed verbal learning and semantic fluency tasks via automated phone or app\u2010based platforms. SB\u2010C performance was compared to Mini\u2010Mental State Examination, Clinical Dementia Rating, Preclinical Alzheimer Cognitive Composite 5, and cerebrospinal fluid amyloid beta and phosphorylated tau181 biomarker status.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      SB\u2010C significantly differentiated cognitively unimpaired and impaired groups (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), correlated with standard cognitive measures, and showed moderate\u2010to\u2010high area under the curve (0.56\u20130.82) for classifying biomarker positivity, with strongest results in BioFINDER\u2010Primary Care.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>SB\u2010C is a scalable, remote speech\u2010derived marker associated with cognitive status and AD biomarker group differences.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71462","type":"journal-article","created":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T03:05:53Z","timestamp":1779159953000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Speech\u2010based digital cognitive assessment for clinical trials: Detecting cognitive impairment stages and AD biomarker relations across European cohorts"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9960-9657","authenticated-orcid":false,"given":"Alexandra","family":"K\u00f6nig","sequence":"first","affiliation":[{"name":"ki:elements GmbH  Saarbr\u00fccken Germany"},{"name":"Cobtek (Cognition\u2010Behaviour\u2010Technology) Lab FRIS\u2010University C\u00f4te d'azur  Nice France"},{"name":"Centre Hospitalier et Universitaire, Clinique G\u00e9riatrique du Cerveau et du Mouvement, Centre M\u00e9moire de Ressources et de Recherche Universit\u00e9 C\u00f4te d'Azur  Nice France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Tr\u00f6ger","sequence":"additional","affiliation":[{"name":"ki:elements GmbH  Saarbr\u00fccken Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Mallick","sequence":"additional","affiliation":[{"name":"ki:elements GmbH  Saarbr\u00fccken Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5178-3234","authenticated-orcid":false,"given":"Nicklas","family":"Linz","sequence":"additional","affiliation":[{"name":"ki:elements GmbH  Saarbr\u00fccken Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6202-6906","authenticated-orcid":false,"given":"Craig","family":"Ritchie","sequence":"additional","affiliation":[{"name":"Scottish Brain Science  Edinburgh UK"},{"name":"Brain Health and Neurodegenerative Medicine University of St. Andrews  St. Andrews UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9864-8240","authenticated-orcid":false,"given":"Sarah","family":"Gregory","sequence":"additional","affiliation":[{"name":"Scottish Brain Science  Edinburgh UK"},{"name":"Edinburgh Dementia Prevention University of Edinburgh  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9082-4684","authenticated-orcid":false,"given":"Matthew","family":"Hunter","sequence":"additional","affiliation":[{"name":"Brain Health and Neurodegenerative Medicine University of St. Andrews  St. Andrews UK"},{"name":"Edinburgh Dementia Prevention University of Edinburgh  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kay","family":"Johnson","sequence":"additional","affiliation":[{"name":"Edinburgh Dementia Prevention University of Edinburgh  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3454-800X","authenticated-orcid":false,"given":"Gonzalo S\u00e1nchez","family":"Benavides","sequence":"additional","affiliation":[{"name":"Barcelona\u03b2eta Brain Research Center (BBRC) Pasqual Maragall Foundation  Barcelona Spain"},{"name":"IMIM (Hospital del Mar Medical Research Institute)  Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Fragilidad y Envejecimiento Saludable Instituto de Salud Carlos III  Madrid 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