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Basic and clinical research studies provide strong evidence that sex\u2010specific differences contribute to AD complexity. Additionally, sex\u2010specific interactions between apolipoprotein E (\n                      <jats:italic>APOE<\/jats:italic>\n                      ) \ud835\udf004, the primary genetic risk factor of AD, and AD\u2010associated neurodegenerative processes are well documented. However, there has been no comprehensive investigation into the interplay between sex and\n                      <jats:italic>APOE<\/jats:italic>\n                      genotypes at the single\u2010cell level.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      In this study, we systematically explore sex\u2010 and\n                      <jats:italic>APOE<\/jats:italic>\n                      \u2010associated differences in single\u2010cell transcriptomics in AD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Our work provides a high\u2010resolution landscape of sex and\n                      <jats:italic>APOE<\/jats:italic>\n                      genotype\u2010specific transcriptomic changes across 54 high\u2010resolution cell types in AD and highlights genes and brain cell populations that show significant sex\u2010 and\n                      <jats:italic>APOE<\/jats:italic>\n                      \u2010specific differences in AD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>\n                      This study lays the groundwork for understanding the complex molecular mechanisms of AD and informs the development of targeted sex\u2010 and\n                      <jats:italic>APOE<\/jats:italic>\n                      \u2010stratified interventions for AD.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71463","type":"journal-article","created":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T03:22:22Z","timestamp":1778469742000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Single\u2010cell transcriptomic analysis reveals\n                    <i>APOE<\/i>\n                    genotype\u2010dependent sex differences in Alzheimer's disease"],"prefix":"10.1002","volume":"22","author":[{"given":"Gefei","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Genetics and Genomic Sciences Icahn School of Medicine at Mount Sinai  New York New York USA"},{"name":"Mount Sinai Center for Transformative Disease Modeling Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abigail","family":"Thorpe","sequence":"additional","affiliation":[{"name":"Department of Genetics and Genomic Sciences Icahn School of Medicine at Mount Sinai  New York New York USA"},{"name":"Mount Sinai Center for Transformative Disease Modeling Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Genetics and Genomic Sciences Icahn School of Medicine at Mount Sinai  New York New York USA"},{"name":"Mount Sinai Center for Transformative Disease Modeling Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erming","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Genetics and Genomic Sciences Icahn School of Medicine at Mount Sinai  New York New York USA"},{"name":"Mount Sinai Center for Transformative Disease Modeling Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison","family":"Goate","sequence":"additional","affiliation":[{"name":"Department of Genetics and Genomic Sciences Icahn School of Medicine at Mount Sinai  New York New York USA"},{"name":"Ronald M. 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