{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T10:16:00Z","timestamp":1783246560156,"version":"3.54.6"},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000083","name":"Directorate for Computer and Information Science and Engineering","doi-asserted-by":"publisher","award":["CNS1920182"],"award-info":[{"award-number":["CNS1920182"]}],"id":[{"id":"10.13039\/100000083","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P30AG066506"],"award-info":[{"award-number":["P30AG066506"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp; Dementia"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>This study aimed to investigate whether sleep quality predicts cognitive\/functional decline, and whether Alzheimer's disease (AD) pathology modifies these relationships.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>The Pittsburgh Sleep Quality Index was administered to 326 older adults (113 cognitively normal, 192 mild cognitive impairment, 21 dementia; mean age\u00a0=\u00a066.4\u00a0\u00b1\u00a08.0 years) enrolled in the 1Florida Alzheimer's Disease Research Center. The Clinical Dementia Rating Sum of Boxes (CDR\u2010SB) assessed cognitive\/functional decline at baseline and over time. Moderators included hippocampal volume (HV), amyloid beta (A\u03b2) positron emission tomography, and plasma phosphorylated tau (p\u2010tau)217.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Cross\u2010sectionally, longer sleep duration and later wake time were associated with worse CDR\u2010SB, with stronger associations observed among individuals with higher A\u03b2 and p\u2010tau217 levels, and smaller HV. Longitudinally, prolonged sleep duration was associated with faster cognitive decline, particularly in individuals with elevated A\u03b2 or p\u2010tau217 levels and smaller hippocampal volumes at baseline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Prolonged sleep duration and later wake times predicted worsening cognitive performance, and these effects were strengthened by greater AD pathology.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71470","type":"journal-article","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T10:06:58Z","timestamp":1780481218000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Associations among sleep quality, cognitive decline, and Alzheimer's disease pathology in older adults: A longitudinal study"],"prefix":"10.1002","volume":"22","author":[{"given":"Layaly","family":"Shihadeh","sequence":"first","affiliation":[{"name":"Department of Psychology Charles E. Schmidt College of Science, Florida Atlantic University  Davie Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2656-9505","authenticated-orcid":false,"given":"M\u00f3nica","family":"Rosselli","sequence":"additional","affiliation":[{"name":"Department of Psychology Charles E. Schmidt College of Science, Florida Atlantic University  Davie Florida USA"},{"name":"1Florida Alzheimer's Disease Research Center  Miami Beach and Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Conniff","sequence":"additional","affiliation":[{"name":"Department of Psychology Charles E. Schmidt College of Science, Florida Atlantic University  Davie Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Breton","family":"Asken","sequence":"additional","affiliation":[{"name":"1Florida Alzheimer's Disease Research Center  Miami Beach and Gainesville Florida USA"},{"name":"Department of Clinical and Health Psychology College of Public Health and Health Professions, University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia","family":"Goytizolo","sequence":"additional","affiliation":[{"name":"Department of Psychology Charles E. Schmidt College of Science, Florida Atlantic University  Davie Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Warren","family":"Barker","sequence":"additional","affiliation":[{"name":"1Florida Alzheimer's Disease Research Center  Miami Beach and Gainesville Florida USA"},{"name":"Wien Center for Alzheimer's Disease and Memory Disorders Mount Sinai Medical Center  Miami Beach Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily F.","family":"Matusz","sequence":"additional","affiliation":[{"name":"1Florida Alzheimer's Disease Research Center  Miami Beach and Gainesville Florida USA"},{"name":"Department of Clinical and Health Psychology College of Public Health and Health Professions, University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angel","family":"Collie","sequence":"additional","affiliation":[{"name":"Department of Clinical and Health Psychology College of Public Health and Health Professions, University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen A.","family":"Coombes","sequence":"additional","affiliation":[{"name":"1Florida Alzheimer's Disease Research Center  Miami Beach and Gainesville Florida USA"},{"name":"Department of Applied Physiology and Kinesiology University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Armstrong","sequence":"additional","affiliation":[{"name":"1Florida Alzheimer's Disease Research Center  Miami Beach and Gainesville Florida USA"},{"name":"Department of Neurology University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Idaly","family":"Velez\u2010Uribe","sequence":"additional","affiliation":[{"name":"1Florida Alzheimer's Disease Research Center  Miami Beach and Gainesville Florida USA"},{"name":"Wien Center for Alzheimer's Disease and Memory Disorders Mount Sinai Medical Center  Miami Beach Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malek","family":"Adjouadi","sequence":"additional","affiliation":[{"name":"1Florida Alzheimer's Disease Research Center  Miami Beach and Gainesville Florida USA"},{"name":"Center for Advanced Technology and Education College of Engineering, Florida International University  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glenn E.","family":"Smith","sequence":"additional","affiliation":[{"name":"1Florida Alzheimer's Disease Research Center  Miami Beach and Gainesville Florida USA"},{"name":"Department of Clinical and Health Psychology College of Public Health and Health Professions, University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranjan","family":"Duara","sequence":"additional","affiliation":[{"name":"1Florida Alzheimer's Disease Research Center  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