{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T08:06:41Z","timestamp":1790928401723,"version":"4.1.0"},"reference-count":196,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T00:00:00Z","timestamp":1779062400000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Type 2 diabetes (T2D) and Alzheimer's disease (AD) are both increasing exponentially worldwide. T2D has also been identified as one of 14 modifiable risk factors for dementia, but the mechanism is unknown. T2D could promote dementia via vascular or AD neuropathological changes, and mechanistic hypotheses include central insulin resistance and T2D's peripheral inflammation promoting central inflammation. Here we examine these different hypotheses by reviewing the recent literature in combination with re\u2010analysis of\n                    <jats:italic>post mortem<\/jats:italic>\n                    brain tissue molecular data. Collectively, recent studies and single\u2010cell transcriptomic data suggest that peripheral lipid anomalies and inflammation seen in T2D act together to reduce brain\u2013blood barrier integrity, facilitating aberrant immune signaling between the periphery and the brain. The subsequent promotion of AD\u2010specific microglial subtypes is the most likely mechanism linking T2D and AD. These AD\u2010specific microglial subtypes may be reduced by therapeutic targeting of triggering receptor expressed on myeloid cells 2\u2013apolipoprotein E signaling pathway.\n                  <\/jats:p>","DOI":"10.1002\/alz.71471","type":"journal-article","created":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T03:21:03Z","timestamp":1779160863000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["How does type 2 diabetes modify the risk of Alzheimer's disease?"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2493-9736","authenticated-orcid":false,"given":"G. 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