{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T04:32:27Z","timestamp":1791952347257,"version":"4.3.4"},"reference-count":45,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000061","name":"Fogarty International Center","doi-asserted-by":"publisher","award":["D43TW012455"],"award-info":[{"award-number":["D43TW012455"]}],"id":[{"id":"10.13039\/100000061","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["SG\u201020\u2010725707"],"award-info":[{"award-number":["SG\u201020\u2010725707"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>\n                      Pathogenic progranulin (\n                      <jats:italic>GRN)<\/jats:italic>\n                      variants are among the main genetic causes of frontotemporal lobar degeneration (FTLD). These variants have been predominantly reported in European cohorts, but their characterization in Latin America remains scarce. We describe two Colombian cases with novel\n                      <jats:italic>GRN<\/jats:italic>\n                      variants with amnestic and semantic syndromes leading to an initial diagnosis of Alzheimer's disease (AD).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We conducted clinical, neuropsychological, neuroimaging, and genetic analysis. Biomarkers were included for one case.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      At 42 years old, Case 1 presented a predominant amnestic profile and carried the\n                      <jats:italic>GRN<\/jats:italic>\n                      c.21\n                      <jats:italic>G\u00a0<\/jats:italic>\n                      &gt;\u00a0A (p.Trp7*) variant. Case 2 debuted with a semantic impairment at 62 years old and was a carrier of\n                      <jats:italic>GRN<\/jats:italic>\n                      c.1098T\u00a0&gt;\u00a0A (p.Cys366*) variant. Brain imaging revealed asymmetric temporal atrophy, and biomarkers supported diagnosis of FTLD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>\n                      <jats:italic>GRN<\/jats:italic>\n                      variants can mimic early\u2010onset AD. An integrative approach including serial clinical, genetic, brain imaging, and biomarker analysis are essential for diagnosing Amnestic variants of FTLD in admixed genetic populations.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71475","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T03:57:47Z","timestamp":1779335867000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Phenotypic diversity of frontotemporal lobar degeneration in two novel\n                    <i>GRN<\/i>\n                    variants from Colombia"],"prefix":"10.1002","volume":"22","author":[{"given":"Juan Pablo","family":"Barbosa\u2010Carvajal","sequence":"first","affiliation":[{"name":"Grupo de Neurociencias de Antioquia, Facultad de Medicina Universidad de Antioquia  Medell\u00edn 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Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Gelvez","sequence":"additional","affiliation":[{"name":"Facultada de Medicina, Instituto de Gen\u00e9tica Humana Pontifica Universidad Javeriana  Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greizy","family":"L\u00f3pez","sequence":"additional","affiliation":[{"name":"Facultada de Medicina, Instituto de Gen\u00e9tica Humana Pontifica Universidad Javeriana  Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Reyes","sequence":"additional","affiliation":[{"name":"Departamento de Psiquiatr\u00eda y Salud Mental, Facultad de Medicina Pontificia Universidad Javeriana  Bogot\u00e1 Colombia"},{"name":"Hospital Universitario San Ignacio  Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elkin","family":"Garc\u00eda\u2010Cifuentes","sequence":"additional","affiliation":[{"name":"Grupo de Neurociencias de Antioquia, Facultad de Medicina Universidad de Antioquia  Medell\u00edn Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Aguill\u00f3n","sequence":"additional","affiliation":[{"name":"Grupo de Neurociencias de Antioquia, Facultad de Medicina Universidad de Antioquia  Medell\u00edn Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana","family":"Acosta\u2010Uribe","sequence":"additional","affiliation":[{"name":"Grupo de Neurociencias de Antioquia, Facultad de Medicina Universidad de Antioquia  Medell\u00edn Colombia"},{"name":"Neuroscience Research Institute and Department of Molecular, Cellular and Developmental Biology University of California Santa Barbara  Santa Barbara California 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