{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T06:00:38Z","timestamp":1785477638951,"version":"3.56.0"},"reference-count":75,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T00:00:00Z","timestamp":1779148800000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01MH129282"],"award-info":[{"award-number":["R01MH129282"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R34NS127101"],"award-info":[{"award-number":["R34NS127101"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["P50NS123067"],"award-info":[{"award-number":["P50NS123067"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["T32NS007222"],"award-info":[{"award-number":["T32NS007222"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["T32NS076401"],"award-info":[{"award-number":["T32NS076401"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P30AG072931"],"award-info":[{"award-number":["P30AG072931"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["F31AG087629"],"award-info":[{"award-number":["F31AG087629"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["AARG\u2010NTF\u201021\u2010846572"],"award-info":[{"award-number":["AARG\u2010NTF\u201021\u2010846572"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","award":["T32DC000011"],"award-info":[{"award-number":["T32DC000011"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>The degeneration of basal forebrain cholinergic neurons is a key pathophysiological feature of Alzheimer's disease (AD). These cholinergic neurons target cortical neurons including those in the granular retrosplenial cortex (RSG) to facilitate essential\u00a0cognitive functions. At the cellular level, acetylcholine supports working memory by inducing persistent firing that outlasts the stimulus, but how such cholinergic\u2010induced persistent firing is altered in AD remains unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Using multiscale molecular and cellular analyses, we investigated neuron type\u2013specific transcriptomic and physiological impairments of cholinergic persistent signaling in the RSG of 5xFAD mice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Cholinergic inputs to RSG were reduced in 5xFAD mice. Expression of the\n                      <jats:italic>Chrm1<\/jats:italic>\n                      gene encoding M1 muscarinic receptors was also reduced in RSG neurons, coupled with impaired cellular persistent firing.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>The loss of M1 receptors suggests that allosteric M1 modulators being considered for treatment of AD symptoms may not be as effective on key cell types, necessitating further multiscale investigation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71490","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T03:26:07Z","timestamp":1779247567000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Reciprocal molecular and cellular cholinergic working memory impairments in Alzheimer's disease model mice"],"prefix":"10.1002","volume":"22","author":[{"given":"Chloe I.","family":"Rybicki\u2010Kler","sequence":"first","affiliation":[{"name":"Department of Psychology University of Michigan  Ann Arbor Michigan USA"},{"name":"Neuroscience Graduate Program University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isla A. W.","family":"Brooks","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izabela","family":"Jedrasiak\u2010Cape","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cassandra","family":"Avila","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Brouns","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Lekander","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3300-7658","authenticated-orcid":false,"given":"Omar J.","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Michigan  Ann Arbor Michigan USA"},{"name":"Neuroscience Graduate Program University of Michigan  Ann Arbor Michigan USA"},{"name":"Department of Biomedical Engineering University of Michigan  Ann Arbor Michigan USA"},{"name":"Morris K. Udall Center of Excellence for Parkinson's Disease University of Michigan  Ann Arbor Michigan USA"},{"name":"Center for Computational Medicine and Bioinformatics University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896\u20106273(03)00288\u20105"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms3760"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhq022"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2350\u201017.2018"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0053472"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2009.02.023"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306\u20104522(83)90108\u20102"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1997.78.3.1743"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0006\u20108993(00)02766\u20109"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12826"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhy150"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresrev.2004.08.006"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1305\u201019.2019"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/59.4.308"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1586\/14737175.8.11.1703"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.23415"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2009.12.044"},{"key":"e_1_2_8_19_1","first-page":"161","volume-title":"Handbook of Clinical Neurology","author":"Fisher A","year":"2025"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460\u20109568.2011.07736.x"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5154\u201008.2009"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2013.06.027"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1388\u201023.2023"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2025.102804"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1366\u201009.2009"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP273627"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16\u201012\u201003848.1996"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP275194"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.08.052"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adj4897"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2017.04.036"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhy142"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593\u2010019\u20100355\u2010x"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2019.05.034"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2022.11.006"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/110.6.1631"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.04.027"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.3389\/fninf.2011.00007"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1200506109"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1825\u201013.2013"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593\u2010019\u20100355\u2010x"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.62207"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.109717.1"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460\u20109568.2003.02999.x"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1097\/WAD.0b013e31802f243e"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2015.03.016"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0890\u201021.2022"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2023.12.014"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adt8976"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.12.093"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-025-03257-w"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1388\u201023.2023"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1998.80.3.1197"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.69065"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cels.2018.11.005"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41592\u2010019\u20100619\u20100"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010023\u201006812\u2010z"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.4091"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1101\/2024.09.17.613545"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btad547"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2009.09.024"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19970224)378:4<454::AID-CNE2>3.0.CO;2-1"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2018.11.035"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2020.11.011"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.04.021"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2023.112206"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1101\/2025.05.04.652144"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006\u20108993(95)00422\u2010m"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0361\u20109230(00)00287\u20102"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.14089"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.61.11.1491"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1177\/1533317512436805"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2015.03.016"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028\u20103932(90)90024\u2010I"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0010\u20109452(08)70479\u20109"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1159\/000109572"}],"container-title":["Alzheimer's &amp; Dementia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.71490","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/alz.71490","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.71490","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T05:26:45Z","timestamp":1785475605000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz.71490"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":75,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1002\/alz.71490"],"URL":"https:\/\/doi.org\/10.1002\/alz.71490","archive":["Portico"],"relation":{},"ISSN":["1552-5260","1552-5279"],"issn-type":[{"value":"1552-5260","type":"print"},{"value":"1552-5279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"2026-01-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71490"}}