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Given widespread deficits observed in sporadic early\u2010onset Alzheimer's disease (EOAD), however, it is unclear if examining cognitive dispersion shows benefit in this condition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>A total of 309 participants (188 amyloid\u2010positive EOAD, 43 amyloid\u2010negative early\u2010onset dementia [EOnonAD], 78 cognitively normal [CN]) completed neuropsychological testing twice over 12 months. Dispersion\u2010related differences among groups were assessed, as was cognitive dispersion's capacity to predict domain\u2010specific cognitive trajectories, and its convergence with imaging biomarkers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>EOAD participants displayed higher cognitive dispersion than EOnonAD participants, and associations with EOAD\u2010specific biomarkers. Additionally, cognitive dispersion was associated with 12\u2010month reliable change across several cognitive domains.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>These preliminary results examine cognitive dispersion in sporadic EOAD. When used with baseline cognitive performance, cognitive dispersion measures may enrich future clinical trials in EOAD by enhancing treatment monitoring over time.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71492","type":"journal-article","created":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T03:19:55Z","timestamp":1779160795000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cognitive dispersion profiles and prediction of cognitive change in early\u2010onset dementias: Results from LEADS"],"prefix":"10.1002","volume":"22","author":[{"given":"Dustin B.","family":"Hammers","sequence":"first","affiliation":[{"name":"Department of Neurology Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elodie","family":"Foster","sequence":"additional","affiliation":[{"name":"Department of Neurology Indiana University School 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