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Dementia"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Both short and long sleep duration have been associated with Alzheimer's disease (AD) risk, yet the nature of the non\u2010linear associations between sleep quantity and blood\u2010based biomarkers of AD and neurodegeneration remains understudied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Among 2410 Framingham Heart Study participants (mean age: 70.0\u00a0\u00b1\u00a08.45\u00a0years; 55.2% female), we examined associations between self\u2010reported sleep duration and plasma phosphorylated tau (p\u2010tau)181, total tau, neurofilament light chain, and glial fibrillary acidic protein using restricted cubic splines (RCS) and categorical comparisons (\u2264 6, &gt; 6\u2013&lt; 9 reference; \u2265 9\u00a0hours).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      RCS revealed non\u2010linear associations between sleep duration and p\u2010tau181 (overall\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.005; non\u2010linearity\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.002), with higher levels at \u2265 8.5\u00a0hours, after adjusting for age, sex, apolipoprotein E \u03b54 genotype, sleep apnea, depression, and kidney function. Categorical comparisons showed no association in adjusted models.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Sleep duration exhibits robust non\u2010linear associations with p\u2010tau181. Findings underscore the importance of non\u2010linear modeling in relating sleep to blood\u2010based biomarkers. Longitudinal studies are needed to clarify temporal relationships and mechanistic pathways.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71499","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T03:19:57Z","timestamp":1779247197000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Non\u2010linear associations between sleep duration and plasma p\u2010tau181 in the Framingham Heart Study"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4633-5052","authenticated-orcid":false,"given":"Vanessa M.","family":"Young","sequence":"first","affiliation":[{"name":"Glenn Biggs Institute for Alzheimer's &amp; Neurodegenerative Diseases The University of Texas Health Science Center at San Antonio  San Antonio Texas USA"},{"name":"Joe R. and Teresa Lozano Long School of Medicine The University of Texas Health Science Center at San Antonio  San 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