{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T13:24:02Z","timestamp":1789219442044,"version":"build-2803163510"},"reference-count":68,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T00:00:00Z","timestamp":1779753600000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["PTCG\u201020\u2010700751"],"award-info":[{"award-number":["PTCG\u201020\u2010700751"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002202","name":"Toronto Rehabilitation Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002202","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012498","name":"Alzheimer Society Research Program","doi-asserted-by":"publisher","award":["ASRP #21\u201011"],"award-info":[{"award-number":["ASRP #21\u201011"]}],"id":[{"id":"10.13039\/100012498","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Alzheimer's disease (AD) is characterized by synaptopathy, a neuropathological feature that can contribute to underlying cognitive decline. Here, we evaluate potential cerebrospinal fluid (CSF) and blood\u2010based synaptic biomarkers in AD dementia and its earliest clinical stage, mild cognitive impairment (MCI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Articles that measured a subset of CSF and\/or blood\u2010based synaptic biomarkers in AD dementia, MCI, and\/or healthy controls were included. A random\u2010effects model was used to determine standardized mean differences and 95% confidence intervals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>In total, 65 study cohorts were included for meta\u2010analysis and 12 for qualitative review. Several CSF (synaptosomal\u2010associated protein 25 [SNAP\u201025], growth\u2010associated protein 43 [GAP\u201043], neuronal pentraxin receptor, neuronal pentraxin\u20101, neuronal pentraxin\u20102, synaptotagmin\u20101, syntaxin\u20101B, and vesicle\u2010associated membrane protein 2) and blood\u2010based (SNAP\u201025, GAP\u201043, and synaptotagmin\u20101) synaptic biomarkers were altered in AD dementia and\/or MCI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Further evaluation of these identified biomarkers may enrich our understanding of AD pathophysiology and disease trajectory, as well as inform future treatment interventions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71501","type":"journal-article","created":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T03:25:51Z","timestamp":1779852351000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Synaptic biomarkers in Alzheimer's disease dementia and mild cognitive impairment: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"22","author":[{"given":"Amish","family":"Gaur","sequence":"first","affiliation":[{"name":"Hurvitz Brain Sciences Program Sunnybrook Research Institute  Toronto Ontario Canada"},{"name":"Faculty of Medicine University of Ottawa  Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Wong","sequence":"additional","affiliation":[{"name":"Hurvitz Brain Sciences Program Sunnybrook Research Institute  Toronto Ontario Canada"},{"name":"Department of Pharmacology &amp; Toxicology University of Toronto  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Dementia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.71501","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/alz.71501","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.71501","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T05:25:12Z","timestamp":1785475512000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz.71501"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":68,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1002\/alz.71501"],"URL":"https:\/\/doi.org\/10.1002\/alz.71501","archive":["Portico"],"relation":{},"ISSN":["1552-5260","1552-5279"],"issn-type":[{"value":"1552-5260","type":"print"},{"value":"1552-5279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"2026-01-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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