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Asymptomatic individuals at genetic risk face substantial personal and family implications when considering predictive testing for known familial variants. Genetic counseling and testing (GCT) frameworks remain limited in Latin America (LatAm). Recommendations for GCT in LatAm were developed through an iterative, multidisciplinary consensus process. Evidence inputs included a structured literature review, site\u2010level recommendations from participating LatAm centers, and a qualitative synthesis of focus groups with experienced investigators. The resulting model includes pre\u2010test evaluation, sample collection, result disclosure, and structured follow\u2010up. Core elements comprise mental health assessment, psychoeducation, exploration of expectations and decision\u2010making needs, guided disclosure with emotional support, and a suggested 3\u2010month post\u2010disclosure reassessment using validated psychological measures. Our framework provides structured guidance for the safe and ethical delivery of GCT for ADAD through a multidisciplinary, culturally informed, and patient\u2010centered approach in LatAm.<\/jats:p>","DOI":"10.1002\/alz.71502","type":"journal-article","created":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T06:14:57Z","timestamp":1779948897000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Recommendations for genetic counseling for individuals at risk of autosomal dominant Alzheimer's disease in Latin America"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8282-2945","authenticated-orcid":false,"given":"Daniel A.","family":"Jim\u00e9nez","sequence":"first","affiliation":[{"name":"Translational Neurology and Neurophysiology Lab CICA Oriente Department of Neurological Sciences Faculty of Medicine University of Chile  Santiago Chile"},{"name":"Unidad de Memoria \u2010 Centro de Memoria y Neuropsiquiatr\u00eda (CMYN) Servicio de Neurolog\u00eda Hospital del Salvador y Facultad de Medicina Universidad de Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo M.","family":"Bagnati","sequence":"additional","affiliation":[{"name":"Department of Cognitive Neurology Neuropsychiatry and Neuropsychology Fleni Neurological Research Institute  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa Elena","family":"Flores\u2010Montes","sequence":"additional","affiliation":[{"name":"C\u00ednica de Neuropsiquiatr\u00eda y Demencias. 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