{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T19:27:42Z","timestamp":1789759662228,"version":"4.0.1"},"reference-count":78,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["SG\u201020\u2010725707"],"award-info":[{"award-number":["SG\u201020\u2010725707"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["335293\/Z\/25\/Z"],"award-info":[{"award-number":["335293\/Z\/25\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015442","name":"Global Brain Health Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015442","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008736","name":"Fondo de Fomento al Desarrollo Cient\u00edfico y Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["20I10152"],"award-info":[{"award-number":["20I10152"]}],"id":[{"id":"10.13039\/501100008736","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Informal caregivers are central to dementia care in Latin America and the Caribbean (LAC), yet determinants of caregiver burden remain insufficiently characterized. We conducted a systematic review and meta\u2010analysis of studies examining patient\u2010 and caregiver\u2010related correlates of burden in LAC. Random\u2010effects models pooled Fisher's z\u2010transformed correlations. Forty studies were included, of which 34 (\n                    <jats:italic>n<\/jats:italic>\n                    = 3,082 caregivers) were meta\u2010analyzed. Higher burden was associated with the patient's neuropsychiatric and depressive symptoms, and caregiver depressive and anxiety symptoms. Better patient cognition and quality of life were associated with lower burden. Meta\u2010regressions showed that higher caregiver education strengthened the association between patient depressive symptoms and burden, and a higher proportion of female caregivers strengthened the association between patient cognition and burden. Findings highlight the role of behavioral and affective symptoms and support culturally grounded, gender\u2010sensitive strategies in LAC. High heterogeneity underscores the need for methodological harmonization and further regional research.\n                  <\/jats:p>","DOI":"10.1002\/alz.71506","type":"journal-article","created":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T10:07:48Z","timestamp":1780308468000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Factors linked to informal caregiver burden in dementia across Latin America and the Caribbean: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"22","author":[{"given":"Paula","family":"Quintero\u2010Cardona","sequence":"first","affiliation":[{"name":"Universidad de los Andes  Bogot\u00e1 Colombia"},{"name":"Universidad Europea del Atl\u00e1ntico  Santander Espa\u00f1a"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Alejandra","family":"Tangarife","sequence":"additional","affiliation":[{"name":"Universidad de los Andes  Bogot\u00e1 Colombia"},{"name":"IGC Pharma SAS  Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Blandon","sequence":"additional","affiliation":[{"name":"Universidad de los Andes  Bogot\u00e1 Colombia"},{"name":"Social Research Institute, Institute of Education University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Carlos","family":"Arango\u2010Lasprilla","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Histology University of the Basque Country UPV\/EHU  Leioa Spain"},{"name":"IKERBASQUE Basque Foundation for Science  Bilbao Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agustin","family":"Ibanez","sequence":"additional","affiliation":[{"name":"Barcelona\u03b2eta Brain Research Center (BBRC) Pasqual Maragall Foundation Barcelona Spain"},{"name":"Cognitive Neuroscience Center Universidad de San Andr\u00e9s  Buenos Aires Argentina"},{"name":"Latin American Brain Health Institute (BrainLat) Universidad Adolfo Iba\u00f1ez  Santiago de Chile Chile"},{"name":"Department of Biophysics, School of Medicine Istanbul Medipol University Istanbul"},{"name":"Global Brain Health Institute (GBHI) Trinity College Dublin  Dublin, Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0875-1709","authenticated-orcid":false,"given":"Sandra","family":"Baez","sequence":"additional","affiliation":[{"name":"Universidad de los Andes  Bogot\u00e1 Colombia"},{"name":"Global Brain Health Institute (GBHI) Trinity College Dublin  Dublin, Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,1]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2666\u20107568(21)00031\u20103"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004897"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12202"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.628520"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2017.00221"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.71309"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2666\u20107568(23)00052\u20101"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.7189\/jogh.10.010362"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.2727"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/13557858.2022.2115018"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/geronb\/gbab170"},{"key":"e_1_2_8_13_1","unstructured":"Gali\u00e1nC RubioM EscarozG AlejandreF.Los Sistemas de Cuidado y Apoyo en Am\u00e9rica Latina y el Caribe: un marco para la acci\u00f3n de UNICEF.Panam\u00e1:Oficina Regional Am\u00e9rica Latina y el Caribe;2023."},{"key":"e_1_2_8_14_1","doi-asserted-by":"crossref","unstructured":"FabianiB StampiniM ArancoN BenedettiF Ibarrar\u00e1nP.Caregivers for older people: overburdened and underpaid: evidence from an Inter\u2010American Development Bank Survey in Latin America and the Caribbean. Version 1: June 2024.Inter\u2010American Development Bank;2024. doi:10.18235\/0013053","DOI":"10.18235\/0013053"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1590\/0101\u201060830000000143"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010130764"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010122086"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1017\/s1041610204000468"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/07317115.2025.2477588"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2018.08.002"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0217648"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archger.2025.105977"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.7475\/kjan.2019.31.4.351"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/08952841.2019.1700728"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijnurstu.2025.105299"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/geront\/30.5.583"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/geront\/gnp162"},{"key":"e_1_2_8_28_1","unstructured":"WellsG O'ConnellD PetersonJ.The Newcastle \u2010Ottawa scale (NOS) for assessing the quality if nonrandomized studies in meta\u2010analyses 2011. (accessed August 20 2025).https:\/\/www.ohri.ca\/programs\/clinical_epidemiology\/oxford.asp"},{"key":"e_1_2_8_29_1","doi-asserted-by":"crossref","DOI":"10.3310\/JYWP4049","volume-title":"The effectiveness, cost\u2010effectiveness and policy processes of regulatory, voluntary and partnership policies to improve food environments: an evidence synthesis","author":"Blanchard L","year":"2024"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.3352\/jeehp.2023.20.24"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0025491"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0039471"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.10008"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v036.i03"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/bimj.201000151"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1177\/1536867X0400400204"},{"key":"e_1_2_8_37_1","first-page":"105","article-title":"Neuropsychiatric symptoms as a predictor of caregiver burden in Alzheimer's disease","volume":"2","author":"Allegri RF","year":"2006","journal-title":"Neuropsychiatr Dis Treat"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.15649\/cuidarte.4646"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1177\/1533317509341465"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.4734"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1980\u201057642010DN40300013"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/WAD.0000000000000299"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1590\/1516\u20103180.2024.0446.r1.13062025"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1177\/0891988717743587"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479\u20108301.2012.00407.x"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1590\/s1807\u201059322011000400015"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.regg.2014.03.007"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/psyg.13053"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1590\/1980\u20105764\u2010DN\u20102023\u20100115"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/ggi.13437"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1590\/1980\u201057642021dn15\u2010010014"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1980\u201057642009DN30200011"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1177\/0891988718759601"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1177\/0891988720933355"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.17711\/SM.0185\u20103325.2025.014"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1159\/000107335"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1980\u201057642014DN84000013"},{"key":"e_1_2_8_58_1","first-page":"517","article-title":"Carga, depresi\u00f3n y familismo en cuidadores informales colombianos de pacientes con esquizofrenia y pacientes con demencia. [Burden, depression and familism in Colombian informal caregivers of patients with schizophrenia and patients with dementia.]","volume":"28","author":"Mora\u2010Casta\u00f1eda B","year":"2020","journal-title":"Behav Psychol"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10823\u2010015\u20109270\u20100"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1980\u201057642008DN10400015"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1177\/0891988720915521"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1177\/1471301215617080"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1590\/1980\u201057642018dn12\u2010040011"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.25009\/pys.v24i1.718"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1111\/ggi.12072"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1590\/0004\u2010282x20140155"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610216000508"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1590\/1518\u20108345.0580.2751"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1177\/1533317513505128"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1177\/1043659615573081"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.4321\/S0213-61632008000300004"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1590\/1980\u20105764\u2010DN\u20102022\u20100092"},{"key":"e_1_2_8_73_1","first-page":"1","article-title":"Necesidades familiares y su relaci\u00f3n con las caracter\u00edsticas psicosociales que presentan los cuidadores de personas con demencia","volume":"26","author":"Moreno JA","year":"2010","journal-title":"Psicol Caribe"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.15452\/CEJNM.2018.09.0017"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1097\/WAD.0b013e31816653cc"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1080\/13607863.2017.1337718"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2023.1168414"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1093\/geronb\/gbp096"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1080\/13607860802534658"}],"container-title":["Alzheimer's &amp; Dementia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.71506","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/alz.71506","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.71506","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T04:21:12Z","timestamp":1783311672000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz.71506"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":78,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1002\/alz.71506"],"URL":"https:\/\/doi.org\/10.1002\/alz.71506","archive":["Portico"],"relation":{},"ISSN":["1552-5260","1552-5279"],"issn-type":[{"value":"1552-5260","type":"print"},{"value":"1552-5279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"2025-12-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71506"}}