{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T13:15:01Z","timestamp":1791983701580,"version":"4.4.0"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T00:00:00Z","timestamp":1779840000000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The Alzheimer's Disease Research Centers (ADRC) program, funded by the National Institute on Aging (NIA), is a national network for conducting cutting\u2010edge basic, clinical, and translational Alzheimer's disease (AD) and AD\u2010related dementias (ADRD) research. ADRCs collect clinical, biomarker, neuroimaging, and autopsy data on thousands of longitudinally followed research participants and the well\u2010characterized data and samples generated by the ADRCs are readily available to the research community. Beyond conducting research, the primary objectives of the ADRC program are to train the next generation of multidisciplinary AD\/ADRD researchers and share information with the public, including the latest findings and opportunities to participate in clinical studies. This article provides an overview of the 40\u2010year history of the ADRC program, from its establishment by Congress in 1984 to now, highlighting the AD\/ADRD scientific achievements enabled by the ADRCs, the data, samples, and resources that ADRCs provide, and future directions for the program.<\/jats:p>","DOI":"10.1002\/alz.71511","type":"journal-article","created":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T06:20:58Z","timestamp":1779949258000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Four decades of Alzheimer's disease discoveries, data, and research resources: The NIH Alzheimer's Disease Research Center Program"],"prefix":"10.1002","volume":"22","author":[{"given":"Grayson","family":"Donley","sequence":"first","affiliation":[{"name":"National Institute on Aging National Institutes of Health  Rockville Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Hsiao","sequence":"additional","affiliation":[{"name":"National Institute on Aging National Institutes of Health  Rockville Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Balintfy","sequence":"additional","affiliation":[{"name":"National Institute on Aging National Institutes of Health  Rockville Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Silverberg","sequence":"additional","affiliation":[{"name":"National Institute on Aging National Institutes of Health  Rockville Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,27]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"U.S. Government Publishing Office.Public Health Service Act. 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Content reviewed December 8 2022. Accessed June 5 2025.https:\/\/www.nia.nih.gov\/health\/what\u2010is\u2010dementia"},{"key":"e_1_2_8_19_1","unstructured":"National Institute on Aging.Lewy body dementia: causes symptoms and diagnosis. Accessed June 5 2025.https:\/\/www.nia.nih.gov\/health\/what\u2010lewy\u2010body\u2010dementia\u2010causes\u2010symptoms\u2010and\u2010treatments"},{"key":"e_1_2_8_20_1","unstructured":"National Institute on Aging.Frontotemporal disorders: causes symptoms and treatment. Accessed June 6 2025.https:\/\/www.nia.nih.gov\/health\/what\u2010are\u2010frontotemporal\u2010disorders"},{"key":"e_1_2_8_21_1","unstructured":"National Institute on Aging.Vascular Dementia. Accessed June 6 2025.https:\/\/www.nia.nih.gov\/health\/vascular\u2010dementia"},{"key":"e_1_2_8_22_1","unstructured":"National Institute on Aging.Guidelines proposed for newly defined Alzheimer's\u2010like brain disorder. 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