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However, wake SW (sleep\u2010like SW potentially reflecting local intrusions of sleep) remain unexplored in AD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>A total of 274 older adults with subjective cognitive decline (SCD) (INSIGHT\u2010preAD cohort, 76.6\u00a0\u00b1\u00a03.5 years) underwent (i) positron emission tomography (PET) scans for amyloid (A) and neurodegeneration (N), (ii) high\u2010density resting\u2010state electroencephalogram (EEG) recordings to detect wake SW, and (iii) cognitive assessments. PET biomarkers were reassessed 2 years later. We examined wake SW associations with (1) current A\/N status, (2) cognition, and (3) amyloid conversion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      A+N\u2212, A\u2212N+, and A+N+ individuals exhibited lower delta wake SW density than A\u2212N\u2212 participants. Wake SW amplitude (1) was higher in A+N+ than A\u2212N\u2212 individuals, (2) correlated with poorer memory, and (3) predicted A\u2212 to A+ conversion (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0157 A\u2010 stable individuals,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a016 convertors).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Wake SW represent promising early EEG biomarkers for AD pathology and amyloid conversion, facilitating risk stratification before cognitive decline onset.<\/jats:p>\n                  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