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Their association with other AD\u2010related phenotypes\/disease progression remain largely unknown.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      Associations between\n                      <jats:italic>AQP4<\/jats:italic>\n                      variants, self\u2010reported sleep measures, and AD\u2010related phenotypes in cognitively unimpaired individuals with evidence of A\u03b2 accumulation were examined using data from the Australian Imaging, Biomarkers and Lifestyle study.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      <jats:italic>AQP4<\/jats:italic>\n                      variants were directly associated with regional brain volumes, atrophy, and cognition. They were also associated with differences in regional brain volumes and atrophy in interaction with sleep duration, latency, and quality. Finally,\n                      <jats:italic>AQP4<\/jats:italic>\n                      variants were associated with cognitive decline in interaction with sleep disturbances.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>\n                      These findings support a relationship between\n                      <jats:italic>AQP4<\/jats:italic>\n                      and AD phenotypes, both directly and through their interaction with sleep.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71516","type":"journal-article","created":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T06:06:47Z","timestamp":1780121207000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Evidence for direct and sleep\u2010moderated relationships between aquaporin\u20104 genetic variants and Alzheimer's disease phenotypes"],"prefix":"10.1002","volume":"22","author":[{"given":"Tenielle","family":"Porter","sequence":"first","affiliation":[{"name":"Centre for Precision Health Edith Cowan University  Joondalup Western Australia Australia"},{"name":"Collaborative Genomics and Translation Group, School of Medical and Health Sciences Edith Cowan University  Joondalup Western Australia Australia"},{"name":"Curtin Medical School Curtin University  Bentley Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayeisha Milligan","family":"Armstrong","sequence":"additional","affiliation":[{"name":"Centre for Precision Health Edith Cowan University  Joondalup Western Australia Australia"},{"name":"Collaborative Genomics and Translation Group, School of Medical and Health Sciences Edith Cowan University  Joondalup Western Australia Australia"},{"name":"Curtin Medical School Curtin University  Bentley Western 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Research Centre, CSIRO  Herston Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitchell","family":"Turner","sequence":"additional","affiliation":[{"name":"Centre for Precision Health Edith Cowan University  Joondalup Western Australia Australia"},{"name":"School of Medical and Health Sciences Edith Cowan University  Joondalup Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Maruff","sequence":"additional","affiliation":[{"name":"Florey Institute of Neuroscience and Mental Health The University of Melbourne  Parkville Victoria Australia"},{"name":"Cogstate Ltd  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher C.","family":"Rowe","sequence":"additional","affiliation":[{"name":"Department of Molecular Imaging and Therapy Austin Health  Heidelberg Victoria Australia"},{"name":"Florey Institute of Neuroscience and Mental Health The University of Melbourne  Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belinda M.","family":"Brown","sequence":"additional","affiliation":[{"name":"Centre for Precision Health Edith Cowan University  Joondalup Western Australia Australia"},{"name":"Centre for Healthy Ageing, Health Futures Institute, Murdoch University  Murdoch Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor L.","family":"Villemagne","sequence":"additional","affiliation":[{"name":"Centre for Precision Health Edith Cowan University  Joondalup Western Australia Australia"},{"name":"Department of Molecular Imaging and Therapy Austin Health  Heidelberg Victoria Australia"},{"name":"Department of Psychiatry University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie R.","family":"Rainey\u2010Smith","sequence":"additional","affiliation":[{"name":"School of 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