{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T23:01:57Z","timestamp":1788217317039,"version":"build-2803163510"},"reference-count":75,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:00:00Z","timestamp":1779321600000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>We evaluated the effects of astrogliosis on Alzheimer's disease (AD) pathology, co\u2010pathology, and symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Cross\u2010sectional data from 187 non\u2010demented participants were processed to obtain measures of SMBT\u20101 standard uptake value ration (SUVR), plasma glial fibrillary acidic protein (GFAP), \u03b2\u2010amyloid (A\u03b2), Centiloids (CL), tau (CenTauR), white matter hyperintensities (WMH), hippocampal volume (HV), and cognition. Linear regressions evaluated pairwise associations, linear regression interaction terms indicated moderating association, and causal mediation analysis evaluated mediating associations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Astrogliosis was associated with CL (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.01), neurodegeneration (0.05\u00a0&lt;\u00a0\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.1), and global cognition (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.01). Moderation analyses revealed SMBT\u20101 SUVR had an attenuating interaction with CL in respect to CenTauR (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u00a0=\u00a0\u22120.13,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.0006) and memory impairment (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u00a0=\u00a00.064,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.05). Plasma GFAP had an attenuating interaction with CL in respect to CenTauR (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u00a0=\u00a0\u22120.19,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.00001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Reactive astrogliosis is an early and important player in the AD development pathway by having an early attenuating effect against A\u03b2. More work is needed to further understand these complex associations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71520","type":"journal-article","created":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T03:25:21Z","timestamp":1779420321000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Complex interplay of astrogliosis and pathology in preclinical Alzheimer's disease"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8798-1715","authenticated-orcid":false,"given":"Alexandra","family":"Gogola","sequence":"first","affiliation":[{"name":"Department of Radiology School of Medicine, University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davneet","family":"Minhas","sequence":"additional","affiliation":[{"name":"Department of Radiology School of Medicine, University of Pittsburgh  Pittsburgh 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Medicine, University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minjie","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Psychiatry School of Medicine, University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuemei","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Psychiatry School of Medicine, University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anum","family":"Saeed","sequence":"additional","affiliation":[{"name":"Heart and Vascular Institute University of Pittsburgh Medical Center  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Reis","sequence":"additional","affiliation":[{"name":"Heart and Vascular Institute University of Pittsburgh Medical Center  Pittsburgh Pennsylvania 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