{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T03:34:46Z","timestamp":1791862486812,"version":"4.3.4"},"reference-count":23,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100006781","name":"Giovanni Armenise-Harvard Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015250","name":"NIHR Bristol Biomedical Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015250","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100024089","name":"Above and Beyond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100024089","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020276","name":"David Telling Charitable Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020276","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100024190","name":"Bristol and Weston Hospitals Charity","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100024190","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011699","name":"BRACE","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011699","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp; Dementia"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Locus coeruleus (LC) and glymphatic dysfunction have been linked both to Alzheimer's disease (AD) and, recently, to infraslow oscillation (ISO) in sleep spindle (sigma) activity (ISO). Here we hypothesize ISO integrity is a critical link between sleep and AD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We analyzed non\u2010rapid eye movement sleep electroencephalogram (EEG) data from AD participants and controls, extracting ISO peak amplitude, intrinsic frequency, and bandwidth from the sigma\u2010power time\u2010course. We assessed group differences and correlations with plasma biomarkers (A\u03b242\/40, pTau181, pTau217, neurofilament light chain [NfL], glial fibrillary acidic protein [GFAP]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>ISO peak amplitude was significantly reduced in AD, while intrinsic frequency and bandwidth were preserved. ISO peak amplitude showed a trend\u2010level association with A\u03b242\/40, whereas ISO bandwidth was positively associated with NfL, and showed trends with GFAP and lower verbal memory retention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Selective weakening of ISO in AD is consistent with LC dysfunction and impaired glymphatic cycling. ISO may be a novel mechanism and electrophysiological marker linking sleep microarchitecture to AD pathology.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71525","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T11:01:27Z","timestamp":1788865287000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Are infraslow oscillations the missing link between sleep and Alzheimer's?"],"prefix":"10.1002","volume":"22","author":[{"given":"Demetrio","family":"Grollero","sequence":"first","affiliation":[{"name":"Department of Experimental and Clinical Medicine Marche Polytechnic University  Ancona Italy"},{"name":"School of Pharmacy University of Camerino  Camerino Italy"},{"name":"Center for Neuroscience University of Camerino  Camerino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Gabb","sequence":"additional","affiliation":[{"name":"Bristol Medical School University of Bristol  Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Blackman","sequence":"additional","affiliation":[{"name":"Bristol Medical School University of Bristol  Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Heslegrave","sequence":"additional","affiliation":[{"name":"Department of Neurodegenerative Diseases University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa","family":"de Vivo","sequence":"additional","affiliation":[{"name":"School of Pharmacy University of Camerino  Camerino Italy"},{"name":"Center for Neuroscience University of Camerino  Camerino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Coulthard","sequence":"additional","affiliation":[{"name":"Bristol Medical School University of Bristol  Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Bellesi","sequence":"additional","affiliation":[{"name":"Center for Neuroscience University of Camerino  Camerino Italy"},{"name":"School of Biosciences and Veterinary Medicine University of Camerino  Camerino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386\u2010019\u20100478\u20105"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2024.08.008"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2020.101902"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.70247"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2023.106378"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aau6550"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2023.106378"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00042.2018"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.1602026"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593\u2010024\u201001822\u20100"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2021.09.041"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593\u2010022\u201001102\u20109"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2025.114554"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2024.11.027"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2024.114977"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abj2511"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000001252"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abb8739"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12877\u2010023\u201004288\u20100"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2025.109191"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsac286"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2020.04.087"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.00705"}],"container-title":["Alzheimer's &amp; 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