{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T03:23:23Z","timestamp":1788233003276,"version":"build-2803163510"},"reference-count":37,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["RF1AG092412"],"award-info":[{"award-number":["RF1AG092412"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["RF1AG054409"],"award-info":[{"award-number":["RF1AG054409"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["U24NS130411"],"award-info":[{"award-number":["U24NS130411"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp; Dementia"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>The association of sleep duration with Alzheimer's disease (AD) \u2010 related brain atrophy and cognition remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Among 38,816 participants in the UK Biobank, we examined the association between\u00a0sleep duration and a validated machine\u2010learning\u2010derived magnetic resonance imaging (MRI) signature of AD\u2010related atrophy (Spatial Pattern of Abnormality for Recognition of Early AD [SPARE\u2010AD]) and three cognitive test scores using generalized additive models. Independently, electronic health records (EHR) from TriNetX were used to examine the 10\u2010year AD risk associated with insomnia and hypersomnia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Sleep duration exhibited a U\u2010shaped association with SPARE\u2010AD (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.001), Trail Making Tests A and B, and the Digit Symbol Substitution Test (all\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001).\u00a0Short (5\u20136\u00a0hours) and long (9\u201310\u00a0hours) sleep duration were associated with poorer cognitive performance. Both insomnia and hypersomnia showed a high risk for Alzheimer's disease.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>This study demonstrates a U\u2010shaped association between sleep duration and AD\u2010like atrophy and cognition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>These findings show that excessive or insufficient sleep is linked to worse brain health.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71528","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T11:00:34Z","timestamp":1783508434000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association of sleep duration with Alzheimer's disease and cognition"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7374-8798","authenticated-orcid":false,"given":"Filippos","family":"Anagnostakis","sequence":"first","affiliation":[{"name":"Artificial Intelligence in Biomedical Imaging Laboratory (AIBIL), Center for AI and Data Science for Integrated Diagnostics (AI2D), Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"},{"name":"Laboratory of AI and Biomedical Science (LABS) Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cliodhna Kate","family":"O'Toole","sequence":"additional","affiliation":[{"name":"Laboratory of AI and Biomedical Science (LABS) Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guray","family":"Erus","sequence":"additional","affiliation":[{"name":"Artificial Intelligence in Biomedical Imaging Laboratory (AIBIL), Center for AI and Data Science for Integrated Diagnostics (AI2D), Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhivya","family":"Srinivasan","sequence":"additional","affiliation":[{"name":"Artificial Intelligence in Biomedical Imaging Laboratory (AIBIL), Center for AI and Data Science for Integrated Diagnostics (AI2D), Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhan","family":"Cui","sequence":"additional","affiliation":[{"name":"Artificial Intelligence in Biomedical Imaging Laboratory (AIBIL), Center for AI and Data Science for Integrated Diagnostics (AI2D), Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michail","family":"Kokkorakis","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Yale School of Medicine Yale University  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Mailman School of Public Health Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiane","family":"Reitz","sequence":"additional","affiliation":[{"name":"Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Neurology Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam M.","family":"Brickman","sequence":"additional","affiliation":[{"name":"Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Neurology Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Despina","family":"Kontos","sequence":"additional","affiliation":[{"name":"Department of Radiology Columbia University  New York New York USA"},{"name":"Center for Innovation in Imaging Biomarkers and Integrated Diagnostics (CIMBID), Department of Radiology Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Radiology Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sam","family":"Payabvash","sequence":"additional","affiliation":[{"name":"Department of Radiology Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa E.","family":"Konofagou","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace","family":"McIlvain","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feixiong","family":"Cheng","sequence":"additional","affiliation":[{"name":"Cleveland Clinic Genome Center, Lerner Research Institute Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew R.","family":"Baldwin","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Allergy, and Critical Care Medicine Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haochang","family":"Shou","sequence":"additional","affiliation":[{"name":"Artificial Intelligence in Biomedical Imaging Laboratory (AIBIL), Center for AI and Data Science for 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