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However, the predictive accuracy of PRS in diverse populations remains low. Here, we evaluated the predictive accuracy of single\u2010, multi\u2010, and cross\u2010ancestry AD\u2010PRS models across multi\u2010ancestral populations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      We used AD GWAS summary statistics from European, African, Admixed American, and East Asian populations to construct AD\u2010PRS for each target population. Model performance was assessed by estimating odds ratios, R\n                      <jats:sup>2<\/jats:sup>\n                      , and area under the curve.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      The cross\u2010ancestry Bayesian PRS model demonstrated the highest predictive performance in non\u2010European populations. It was significantly associated with poorer cognitive function, lower A\u03b2\n                      <jats:sub>42<\/jats:sub>\n                      cerebrospinal fluid levels, and the most severe category of A\u03b2 and tau neuropathological burden.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Inclusive genetic datasets and cross\u2010ancestry PRS models are needed to enhance the transportability of AD\u2010PRS across multi\u2010ancestral populations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71529","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T03:49:37Z","timestamp":1785296977000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cross\u2010ancestry polygenic risk scores enhance Alzheimer's disease risk prediction in 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Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristine","family":"Yaffe","sequence":"additional","affiliation":[{"name":"Fein Memory and Aging Center, University of California  San Francisco California USA"},{"name":"Department of Psychiatry and Behavioral Sciences University of California  San Francisco California USA"},{"name":"Department of Epidemiology and Biostatistics University of California  San Francisco California USA"},{"name":"San Francisco Veterans Affairs Health Care System  San Francisco California USA"},{"name":"The Center for Population Brain Health University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7274-2634","authenticated-orcid":false,"given":"Jennifer S.","family":"Yokoyama","sequence":"additional","affiliation":[{"name":"Fein Memory and Aging Center, University of California  San Francisco California 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