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Theta power\u2010related cholinergic function and long\u2010term potentiation (LTP) were evaluated in\n                      <jats:italic>\n                        App\n                        <jats:sup>NL\u2010G\u2010F<\/jats:sup>\n                      <\/jats:italic>\n                      KI\/HCNP\u2010pp cKO mice. Molecules associated with the cholinergic\/glutamatergic neurons, amyloid beta (A\u03b2), and inflammation were examined.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Reduced HCNP levels enhanced cognitive impairment, inhibiting theta power and LTP, although without accompanying pathological changes or inflammation. Decreased\n                      <jats:italic>N<\/jats:italic>\n                      \u2010methyl\u2010D\u2010aspartate receptor subunit 2A (NR2A), choline acetyltransferase (ChAT), and Vesicular acetylcholine transporter (VAChT) levels were observed in the hippocampus and ChAT in the medial septal nucleus (MSN) of\n                      <jats:italic>\n                        App\n                        <jats:sup>NL\u2010G\u2010F<\/jats:sup>\n                      <\/jats:italic>\n                      KI\/HCNP\u2010pp cKO mice.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>\n                      Cholinergic dysfunction in HCNP\u2010pp cKO mice exacerbates cognitive dysfunction in\n                      <jats:italic>\n                        App\n                        <jats:sup>NL\u2010G\u2010F<\/jats:sup>\n                      <\/jats:italic>\n                      KI mice. The obtained mouse models are expected to be used to investigate cholinergic dysfunction and amyloid pathogenesis in AD.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71531","type":"journal-article","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T10:00:57Z","timestamp":1780480857000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Reduction in hippocampal cholinergic neurostimulating peptide enhances memory impairment in\n                    <i>\n                      App\n                      <sup>NL\u2010G\u2010F<\/sup>\n                    <\/i>\n                    KI mice"],"prefix":"10.1002","volume":"22","author":[{"given":"Yo","family":"Tsuda","sequence":"first","affiliation":[{"name":"Department of Neurology Nagoya City University Graduate School of Medical Sciences  Nagoya 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