{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T05:14:07Z","timestamp":1783314847556,"version":"3.54.6"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T00:00:00Z","timestamp":1780704000000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>The extent to which non\u2010pathological aging influences plasma biomarkers remains unclear. Here, we investigate factors influencing plasma p\u2010tau217 levels in cognitively unimpaired (CU), amyloid\u2010beta\u2013negative (A\u03b2\u2010) individuals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      Plasma p\u2010tau217 was measured in CU A\u03b2\u2010 positron emission tomography\u2013negative (PET\u2010) participants using two immunoassays (ALZpath\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0360 and LUMIPULSE G1200\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a073). Associations between p\u2010tau217 and age groups (60\u201369, 70\u201379, and 80+ years), apolipoprotein E (\n                      <jats:italic>APOE)<\/jats:italic>\n                      genotype, and gender were evaluated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      ALZpath plasma p\u2010tau217 showed a non\u2010pathological age\u2010related increase (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), and increased percentage within the intermediate zone with age. Lumipulse p\u2010tau217 showed an increase in the percentage of subjects with positive results with age, however, this trend was not significant (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&gt;\u00a00.05). Men had higher levels of p\u2010tau217 only with the ALZpath assay (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.02; Lumipulse:\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.81). No significant associations were found between p\u2010tau217 and\n                      <jats:italic>APOE<\/jats:italic>\n                      genotype.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Our results highlight the importance of incorporating age and sex into the interpretation of plasma p\u2010tau217 particularly in preclinical stages.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71532","type":"journal-article","created":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T06:36:01Z","timestamp":1780814161000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Age\u2010related increase in plasma p\u2010tau217 in amyloid\u2010beta\u2013negative cognitively unimpaired individuals affects diagnostic interpretation"],"prefix":"10.1002","volume":"22","author":[{"given":"Anna E","family":"Mammel","sequence":"first","affiliation":[{"name":"Neurocode USA Inc  Bellingham Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Gonzalez\u2010Ortiz","sequence":"additional","affiliation":[{"name":"Neurocode USA Inc  Bellingham Washington USA"},{"name":"University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Mousavi","sequence":"additional","affiliation":[{"name":"BC Neuroimmunology Laboratory  Vancouver British Columbia Canada"},{"name":"Division of Neurology Department of Medicine University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelsey","family":"Hallett","sequence":"additional","affiliation":[{"name":"Neurocode USA Inc  Bellingham Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Encarnacion","sequence":"additional","affiliation":[{"name":"BC Neuroimmunology Laboratory  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Don","family":"Biehl","sequence":"additional","affiliation":[{"name":"Neurocode USA Inc  Bellingham Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pradip","family":"Gill","sequence":"additional","affiliation":[{"name":"Neurocode USA Inc  Bellingham Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sazan","family":"Ismael","sequence":"additional","affiliation":[{"name":"Division of Neurology Department of Medicine University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Fowler","sequence":"additional","affiliation":[{"name":"The Florey Institute of Neuroscience and Mental Health the University of Melbourne  Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James D.","family":"Doecke","sequence":"additional","affiliation":[{"name":"The Australian e\u2010Health Research Centre Commonwealth Scientific and Industrial Research Organisation  Brisbane Queensland Australia"},{"name":"School of Medical and Health Sciences Edith Cowan University  Joondalup Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larry","family":"Ward","sequence":"additional","affiliation":[{"name":"The Florey Institute of Neuroscience and Mental Health the University of Melbourne  Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Frykman","sequence":"additional","affiliation":[{"name":"Neurocode USA Inc  Bellingham Washington USA"},{"name":"BC Neuroimmunology Laboratory  Vancouver British Columbia Canada"},{"name":"Division of Neurology Department of Medicine University of British Columbia  Vancouver British Columbia Canada"},{"name":"National Reference Lab  Abu Dhabi UAE"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2023.5319"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.14283\/jpad.2022.88"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1515\/cclm\u20102023\u20101434"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14536"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/14789450.2021.1886929"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1997.6908"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000005261"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines12081836"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43587\u2010025\u201000835\u2010z"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awac333"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.095054"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010025\u201003622\u2010w"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.70315"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010024\u201001642\u20101"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2022.5272"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010022\u201002066\u2010w"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2023.06.018"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610209009405"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/dad2.70070"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582\u2010024\u201000977\u20105"},{"key":"e_1_2_9_22_1","doi-asserted-by":"crossref","unstructured":"ArranzJ ZhuN Rubio\u2010GuerraS et\u00a0al.Diagnostic performance of plasma pTau 217 pTau 181 A\u03b2 1\u201042 and A\u03b2 1\u201040 in the LUMIPULSE automated platform for the detection of Alzheimer disease. Preprint posted online December 13 2023. doi:10.21203\/rs.3.rs\u20103725688\/v1","DOI":"10.21203\/rs.3.rs-3725688\/v1"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2020.4201"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2022.5272"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2024.105405"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010025\u201001719\u20105"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024\u2010023\u201000605\u20108"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcae375"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.70319"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.70288"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awad135"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.70535"}],"container-title":["Alzheimer's &amp; Dementia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.71532","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/alz.71532","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.71532","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T04:16:47Z","timestamp":1783311407000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz.71532"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":31,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1002\/alz.71532"],"URL":"https:\/\/doi.org\/10.1002\/alz.71532","archive":["Portico"],"relation":{},"ISSN":["1552-5260","1552-5279"],"issn-type":[{"value":"1552-5260","type":"print"},{"value":"1552-5279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"2026-02-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71532"}}