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We examined whether\n                      <jats:italic>AQP4<\/jats:italic>\n                      genetic variation was associated with AD pathology or modified the association between sleep duration and AD biomarkers.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      A total of 450 dementia\u2010free participants (mean age\u00a0=\u00a058\u00a0\u00b1\u00a09.9; women\u00a0=\u00a054%) from the Framingham Heart Study (FHS) with sleep duration measured by self\u2010report and amyloid\u2010\n                      <jats:italic>\u03b2<\/jats:italic>\n                      (A\n                      <jats:italic>\u03b2<\/jats:italic>\n                      ) and tau burden quantified using positron emission tomography (PET) were analyzed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      <jats:italic>AQP4<\/jats:italic>\n                      was not associated with A\n                      <jats:italic>\u03b2<\/jats:italic>\n                      or tau burden in the overall sample. However, for participants aged less than 60, minor allele carriers displayed lower regional tau burden compared to homozygote majors.\n                      <jats:italic>AQP4<\/jats:italic>\n                      modified the relationship between short sleep (\u22646\u00a0hours) and medial temporal tau; short sleep duration was associated with higher medial temporal tau in minor allele carriers, while the opposite was observed in homozygote majors.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>\n                      <jats:italic>AQP4<\/jats:italic>\n                      genetic variation may influence early tau accumulation and vulnerability to sleep\u2010related AD pathology.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71540","type":"journal-article","created":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T10:07:47Z","timestamp":1780308467000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Influence of an AQP4 haplotype and sleep duration on early Alzheimer's disease"],"prefix":"10.1002","volume":"22","author":[{"given":"Emma L.","family":"Palatsides","sequence":"first","affiliation":[{"name":"Turner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Yiallourou","sequence":"additional","affiliation":[{"name":"Turner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dibya","family":"Himali","sequence":"additional","affiliation":[{"name":"Framingham Heart Study  Framingham Massachusetts USA"},{"name":"Department of Neurology Boston University Chobanian &amp; 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