{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T06:32:36Z","timestamp":1787293956931,"version":"build-2736575974"},"reference-count":208,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100023581","name":"National Science Foundation Graduate Research Fellowship Program","doi-asserted-by":"publisher","award":["2146752"],"award-info":[{"award-number":["2146752"]}],"id":[{"id":"10.13039\/100023581","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010319","name":"Shurl and Kay Curci Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010319","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["T32GM139780"],"award-info":[{"award-number":["T32GM139780"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Stress is increasingly recognized as an important, modifiable factor for Alzheimer's disease (AD), yet its roles in initiation, progression, and outcomes remain incompletely elucidated. Epidemiologic studies link chronic stress, early\u2010life adversity, and trauma to increased AD risk, while experimental models have uncovered mechanisms by which stress hormones directly drive core AD pathological processes, including amyloid beta and tau aggregation, neuroinflammation, and neurodegeneration. Complicating the relationship, brain structures that regulate the stress response are themselves selectively vulnerable to early degeneration in AD. As these circuits degenerate, interpreting changes in stress biomarkers becomes more challenging, with physiological measures potentially decoupling from perceived stress. Here, we review evidence connecting stress to AD pathophysiology as both a risk factor and a driver, examine how the degeneration of stress neuroendocrine systems accelerates disease progression, and discuss implications for intervention and clinical trial design.<\/jats:p>","DOI":"10.1002\/alz.71542","type":"journal-article","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T09:43:52Z","timestamp":1780479832000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Stress, stress systems, and Alzheimer's disease"],"prefix":"10.1002","volume":"22","author":[{"given":"Stephanie G.","family":"Eberly","sequence":"first","affiliation":[{"name":"Dept. of Neuroscience University of California, Berkeley  Berkeley California USA"},{"name":"Dept. of Mechanical Engineering University of California, Berkeley  Berkeley California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chayarndorn","family":"Phumsatitpong","sequence":"additional","affiliation":[{"name":"Dept. of Neuroscience University of California, Berkeley  Berkeley California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine E.","family":"Munro","sequence":"additional","affiliation":[{"name":"Harvard Medical School Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Harvard Medical School Brigham and Women's Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas C.","family":"Neylan","sequence":"additional","affiliation":[{"name":"Dept. of Psychiatry and Behavioral Sciences University of California, San Francisco  San Francisco California USA"},{"name":"San Francisco Veterans Affairs Health Care System  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Kaufer","sequence":"additional","affiliation":[{"name":"Dept. of Neuroscience University of California, Berkeley  Berkeley California USA"},{"name":"Dept. of Integrative Biology University of California, Berkeley  Berkeley California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4334-9424","authenticated-orcid":false,"given":"Alexander J.","family":"Ehrenberg","sequence":"additional","affiliation":[{"name":"Dept. of Neuroscience University of California, Berkeley  Berkeley California USA"},{"name":"Edward and Pearl Fein Memory and Aging Center University of California, San Francisco  San Francisco California USA"},{"name":"Innovative Genomics Institute University of California, Berkeley  Berkeley California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ynstr.2018.04.002"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.70179"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-56071-9"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-181030"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpsc.2016.08.006"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000003537"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2019.00043"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(91)90243-5"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.37.3.535"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1590\/1980-5764-dn-2023-0031"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3999(02)00429-4"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2018.00127"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.31887\/DCNS.2006.8.4\/ssmith"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ynstr.2014.10.004"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcap.12102"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l1255"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.01492"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/13607863.2019.1625304"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1159\/000492177"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/WAD.0000000000000125"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/geronb\/gbad131"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-023-03848-8"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jagp.2016.10.003"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2023.08.122"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-200089"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.093384"},{"key":"e_1_2_9_28_1","first-page":"31","volume-title":"Perceived stress in a probability sample of the United States. The social psychology of health","author":"Cohen S","year":"1988"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0280471"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-024-01592-8"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1155\/jare\/9924448"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjpad.2024.100046"},{"key":"e_1_2_9_33_1","volume-title":"Social Isolation and Loneliness in Older Adults: Opportunities for the Health Care System","author":"National Academies of Sciences E, Medicine","year":"2020"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000201564"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)01296-0"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2018.1012"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1177\/0891988720973759"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yfrne.2023.101061"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurpub\/cky134"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00127-024-02676-4"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.puhe.2025.02.008"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.5888\/pcd20.230182"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40035-023-00355-z"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jagp.2017.05.008"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ynstr.2018.02.003"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.2020.150"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-43884-3"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2016.08.013"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2010.61"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.5711"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12712"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.3389\/fragi.2025.1488528"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.21.1.55"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-025-02042-8"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e38843"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2020.00184"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bj.2022.12.004"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-52406-8"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-025-06721-x"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2006.11.013"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.089648"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2025.03.007"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.093549"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1111\/nan.12387"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2016.06.2362"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1111\/nan.12386"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1177\/2398212820930321"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-22509-1"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci13091322"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.2174\/1567205014666170531082352"},{"key":"e_1_2_9_71_1","article-title":"The Clinical Role of Heart Rate Variability Assessment in Cognitively Impaired Patients and Its Applicability in Community Care Settings: a Systematic Review of the Literature","volume":"16","author":"Attreed A","year":"2024","journal-title":"Cureus"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.neuropsych.17080168"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1483-17.2017"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2012.06.013"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0909586107"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4236-05.2006"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2010.02.001"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2006.06.003"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2018.01.020"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.106362.4"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.70111"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.07.002"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2019.02.010"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-017-0548-3"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2830-04.2004"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4106-09.2009"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3717"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.00371"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox14030255"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI130513"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1993.tb03537.x"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.1006\/nbdi.2001.0395"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.13195"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2011-111328"},{"key":"e_1_2_9_95_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0700148104"},{"key":"e_1_2_9_96_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-141281"},{"key":"e_1_2_9_97_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-011-9788-9"},{"key":"e_1_2_9_98_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5173-06.2007"},{"key":"e_1_2_9_99_1","doi-asserted-by":"publisher","DOI":"10.1080\/10253890.2016.1183119"},{"key":"e_1_2_9_100_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-142844"},{"key":"e_1_2_9_101_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.14.1.147"},{"key":"e_1_2_9_102_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0022-3042.2001.00712.x"},{"key":"e_1_2_9_103_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2012.198"},{"key":"e_1_2_9_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2006.03.007"},{"key":"e_1_2_9_105_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4109"},{"key":"e_1_2_9_106_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.56.8.1094"},{"key":"e_1_2_9_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2021.09.029"},{"key":"e_1_2_9_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2007.03.013"},{"key":"e_1_2_9_109_1","doi-asserted-by":"publisher","DOI":"10.1177\/089198870101400303"},{"key":"e_1_2_9_110_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2797-06.2006"},{"key":"e_1_2_9_111_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0730-11.2011"},{"key":"e_1_2_9_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2021.111477"},{"key":"e_1_2_9_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(00)03026-2"},{"key":"e_1_2_9_114_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddg361"},{"key":"e_1_2_9_115_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2013.135"},{"key":"e_1_2_9_116_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0222113"},{"key":"e_1_2_9_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2020.104769"},{"key":"e_1_2_9_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2025.111548"},{"key":"e_1_2_9_119_1","first-page":"88","article-title":"Restraint Stress\u2010Induced Morphological Changes at the Blood\u2010Brain Barrier in Adult Rats","volume":"8","author":"Santha P","year":"2015","journal-title":"Front Mol Neurosci"},{"key":"e_1_2_9_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2008.01.002"},{"key":"e_1_2_9_121_1","doi-asserted-by":"publisher","DOI":"10.2741\/2174"},{"key":"e_1_2_9_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2015.05.018"},{"key":"e_1_2_9_123_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-021-02348-3"},{"key":"e_1_2_9_124_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2014.38"},{"key":"e_1_2_9_125_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201709069"},{"key":"e_1_2_9_126_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3407"},{"key":"e_1_2_9_127_1","doi-asserted-by":"publisher","DOI":"10.1159\/000520192"},{"key":"e_1_2_9_128_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms231810572"},{"key":"e_1_2_9_129_1","doi-asserted-by":"publisher","DOI":"10.1159\/000548021"},{"key":"e_1_2_9_130_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-13812-z"},{"key":"e_1_2_9_131_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-2-22"},{"key":"e_1_2_9_132_1","doi-asserted-by":"publisher","DOI":"10.1080\/20008198.2021.1956746"},{"key":"e_1_2_9_133_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2007.07.007"},{"key":"e_1_2_9_134_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adr7960"},{"key":"e_1_2_9_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2005.05.009"},{"key":"e_1_2_9_136_1","doi-asserted-by":"publisher","DOI":"10.31887\/DCNS.2006.8.4\/bmcewen"},{"key":"e_1_2_9_137_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2017.4719"},{"key":"e_1_2_9_138_1","doi-asserted-by":"publisher","DOI":"10.1093\/geronj\/45.4.M131"},{"key":"e_1_2_9_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2010.06.011"},{"key":"e_1_2_9_140_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2019.06.3916"},{"key":"e_1_2_9_141_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2007.11.062"},{"key":"e_1_2_9_142_1","doi-asserted-by":"publisher","DOI":"10.1385\/MN:32:3:285"},{"key":"e_1_2_9_143_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04284"},{"key":"e_1_2_9_144_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7266"},{"key":"e_1_2_9_145_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/nlx113"},{"key":"e_1_2_9_146_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-142682"},{"key":"e_1_2_9_147_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-010-0789-4"},{"key":"e_1_2_9_148_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12937"},{"key":"e_1_2_9_149_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1180962"},{"key":"e_1_2_9_150_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20141788"},{"key":"e_1_2_9_151_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-021-00902-8"},{"key":"e_1_2_9_152_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2013.2334"},{"key":"e_1_2_9_153_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0503-19.2019"},{"key":"e_1_2_9_154_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30318-1"},{"key":"e_1_2_9_155_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2024.11.027"},{"key":"e_1_2_9_156_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0275-18.2018"},{"key":"e_1_2_9_157_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.892754"},{"key":"e_1_2_9_158_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2020.101171"},{"key":"e_1_2_9_159_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2023.1154112"},{"key":"e_1_2_9_160_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.2006.163.12.2164"},{"key":"e_1_2_9_161_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2014.10.031"},{"key":"e_1_2_9_162_1","doi-asserted-by":"publisher","DOI":"10.5339\/qmj.2021.33"},{"key":"e_1_2_9_163_1","doi-asserted-by":"publisher","DOI":"10.3233\/ADR-230125"},{"key":"e_1_2_9_164_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsycho.2023.108511"},{"key":"e_1_2_9_165_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2019.08.003"},{"key":"e_1_2_9_166_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1107780"},{"key":"e_1_2_9_167_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.inpsyc.2024.100009"},{"key":"e_1_2_9_168_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjno-2022-000344"},{"key":"e_1_2_9_169_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbih.2023.100592"},{"key":"e_1_2_9_170_1","first-page":"2894","article-title":"Change of serum ACTH and cortisol levels in Alzheimer disease and mild cognition impairment","volume":"90","author":"Lei JK","year":"2010","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"e_1_2_9_171_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291700033675"},{"key":"e_1_2_9_172_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197-4580(94)00159-6"},{"key":"e_1_2_9_173_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1092852913000096"},{"key":"e_1_2_9_174_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbih.2024.100849"},{"key":"e_1_2_9_175_1","doi-asserted-by":"publisher","DOI":"10.1038\/271"},{"key":"e_1_2_9_176_1","doi-asserted-by":"publisher","DOI":"10.1210\/edrv-7-3-284"},{"key":"e_1_2_9_177_1","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.12289"},{"key":"e_1_2_9_178_1","doi-asserted-by":"publisher","DOI":"10.1002\/trc2.12257"},{"key":"e_1_2_9_179_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awz193"},{"key":"e_1_2_9_180_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-019-0437-x"},{"key":"e_1_2_9_181_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2020.601519"},{"key":"e_1_2_9_182_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2017.02.025"},{"key":"e_1_2_9_183_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2022.148070"},{"key":"e_1_2_9_184_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2826.1999.00337.x"},{"key":"e_1_2_9_185_1","first-page":"373","article-title":"Lateral Hypothalamus Corticotropin\u2010releasing Hormone Receptor\u20101 Inhibition and Modulating Stress\u2010induced Anxiety Behavior","volume":"13","author":"Eghtesad M","year":"2021","journal-title":"Basic Clin Neurosci"},{"key":"e_1_2_9_186_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-024-02860-9"},{"key":"e_1_2_9_187_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2022.109061"},{"key":"e_1_2_9_188_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26072940"},{"key":"e_1_2_9_189_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2016.11.018"},{"key":"e_1_2_9_190_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dcn.2022.101165"},{"key":"e_1_2_9_191_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-023-01986-4"},{"key":"e_1_2_9_192_1","doi-asserted-by":"publisher","DOI":"10.1101\/lm.037291.114"},{"key":"e_1_2_9_193_1","doi-asserted-by":"publisher","DOI":"10.1210\/edrv-12-2-118"},{"key":"e_1_2_9_194_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2016.08.010"},{"key":"e_1_2_9_195_1","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcab125"},{"key":"e_1_2_9_196_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/209570"},{"key":"e_1_2_9_197_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-143009"},{"key":"e_1_2_9_198_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.pbr.2025.08.015"},{"key":"e_1_2_9_199_1","doi-asserted-by":"publisher","DOI":"10.1089\/acm.2016.0346"},{"key":"e_1_2_9_200_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2025.1648225"},{"key":"e_1_2_9_201_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-200652"},{"key":"e_1_2_9_202_1","doi-asserted-by":"publisher","DOI":"10.1515\/revneuro-2017-0066"},{"key":"e_1_2_9_203_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13699"},{"key":"e_1_2_9_204_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpdd.5"},{"key":"e_1_2_9_205_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40520-015-0353-0"},{"key":"e_1_2_9_206_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00054"},{"key":"e_1_2_9_207_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2017.01.011"},{"key":"e_1_2_9_208_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.26641"},{"key":"e_1_2_9_209_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awab452"}],"container-title":["Alzheimer's &amp; Dementia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.71542","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/alz.71542","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.71542","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T04:29:49Z","timestamp":1783312189000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz.71542"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":208,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1002\/alz.71542"],"URL":"https:\/\/doi.org\/10.1002\/alz.71542","archive":["Portico"],"relation":{},"ISSN":["1552-5260","1552-5279"],"issn-type":[{"value":"1552-5260","type":"print"},{"value":"1552-5279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"2026-02-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71542"}}