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Prevalence and 5\u20137 year transition of high\u2010risk plasma p\u2010tau217 status was determined among community\u2010dwelling 70\u2010year\u2010olds.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>High\u2010risk plasma p\u2010tau217 prevalence was 3.6% at age 70 and 7.0% at age 75\u201377 years. Eighty\u2010nine percent remained low\u2010risk and 4% converted to high\u2010risk at follow\u2010up. Prevalence of dementia at follow\u2010up was 1.7% if remaining in the low\u2010risk group and 21.4% if transitioning to the high\u2010risk group. Prevalence of dementia among participants staying in the high\u2010risk group was 16.7% at follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Individuals with low\u2010risk plasma p\u2010tau217 were unlikely to transition over 5\u20137 years. However, transitioning to a higher risk\u2010category was associated with a higher prevalence of cognitive disability.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71545","type":"journal-article","created":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T03:36:03Z","timestamp":1780889763000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prevalence of high\u2010risk plasma p\u2010tau217 levels and 5\u2010year transition of risk status in 70\u2010year\u2010olds"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5168-2975","authenticated-orcid":false,"given":"Anna","family":"Dittrich","sequence":"first","affiliation":[{"name":"Neuropsychiatric Epidemiology Unit Sahlgrenska Academy University of Gothenburg  M\u00f6lndal Sweden"},{"name":"Department of Neuropsychiatry Sahlgrenska University Hospital  Gothenburg, Region V\u00e4stra G\u00f6taland Sweden"},{"name":"Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology the Sahlgrenska Academy at the University of Gothenburg  Gothenburg Sweden"},{"name":"Clinical Dementia Research, Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burak","family":"Arslan","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology the Sahlgrenska Academy at the University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Skillb\u00e4ck","sequence":"additional","affiliation":[{"name":"Neuropsychiatric Epidemiology Unit Sahlgrenska Academy University of Gothenburg  M\u00f6lndal Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Ryd\u00e9n","sequence":"additional","affiliation":[{"name":"Neuropsychiatric Epidemiology 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