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This study characterized CSVD scores and assessed their cognitive associations in older adults with various neurodegenerative diseases and cognitive profiles.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      Baseline data from 958 Comprehensive Assessment of Neurodegeneration and Dementia (COMPASS\u2010ND) study participants were analyzed (19.4% cognitively normal, 14.9% subjective cognitive decline, 40.3% mild cognitive impairment, 25.4% dementia). MRI markers of cerebral vascular injury (lacunes, microbleeds, white matter hyperintensities [WMHs], and enlarged perivascular spaces) were visually rated, and a cumulative CSVD score was generated. Cognition was measured using the Montreal Cognitive Assessment (MoCA), Clinical Dementia Rating\u2010Sum of Boxes (CDR\u2010SB), and a composite neuropsychological battery test\n                      <jats:italic>z<\/jats:italic>\n                      \u2010score.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Higher CSVD scores were associated with greater Hachinski ischemic scores, poorer MoCA performance, worse CDR\u2010SB, and lower composite\n                      <jats:italic>z<\/jats:italic>\n                      \u2010scores. Associations were strongest for cognitive domains of executive function, attention, and learning.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>CSVD burden may further contribute to poorer cognition across neurodegenerative conditions and cognitive profiles.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71546","type":"journal-article","created":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T06:36:51Z","timestamp":1780814211000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Cerebral small vessel disease and cognition in older adults across the neurodegenerative spectrum: insights from the COMPASS\u2010ND study"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7065-1963","authenticated-orcid":false,"given":"Dylan 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