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Oligodendrocytes displayed the largest proportion of\n                      <jats:italic>APOE<\/jats:italic>\n                      *4+ genes. Several genes were druggable and pinpointed\n                      <jats:italic>APOE<\/jats:italic>\n                      *4\u2010stratified drugs or compounds.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>\n                      We identified a set of\n                      <jats:italic>APOE<\/jats:italic>\n                      *4\u2010stratified genes that may be causal for AD through brain cell\u2010type\u2010specific mechanisms. We additionally identified compounds that may shed light on therapeutic avenues for treating AD based on an individual's\n                      <jats:italic>APOE<\/jats:italic>\n                      *4 status.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71552","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T12:21:13Z","timestamp":1782130873000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<i>APOE<\/i>\n                    *4 risk\u2010modifying genes and drug targets in Alzheimer's disease through cell\u2010type\u2010specific genomic analyses"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3842-1815","authenticated-orcid":false,"given":"Youjie","family":"Zeng","sequence":"first","affiliation":[{"name":"Department of Neurology Washington University School of Medicine  St. Louis Missouri 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