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However, associations with Alzheimer's disease (AD) pathology, and whether these associations differ depending on underlying disease risk, remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      We examined associations of actigraphy\u2010derived total volume of physical activity (TVPA), total sleep time (TST), and wake after sleep onset (WASO) with tau burden measured by positron emission tomography (PET) in Braak I\u2013II subregions among 120 cognitively unimpaired older adults. Moderation by\n                      <jats:italic>APOE<\/jats:italic>\n                      \u03b54 carrier status and amyloid positivity, based on amyloid PET, was examined to evaluate risk\u2010dependent associations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Greater WASO was associated with higher tau burden among\n                      <jats:italic>APOE<\/jats:italic>\n                      \u03b54 carriers and amyloid beta (A\u03b2)\u2010positive individuals. TVPA was associated with higher tau burden among A\u03b2\u2010positive individuals and lower tau burden among A\u03b2\u2010negative individuals.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Associations of sleep and physical activity with early tau pathology differ by genetic risk and A\u03b2 status, highlighting the importance of risk stratification.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71555","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T03:32:33Z","timestamp":1781667153000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["APOE \u03b54 and amyloid status moderate the associations between sleep, physical activity, and tau\u2010PET burden in cognitively unimpaired older adults"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0843-6602","authenticated-orcid":false,"given":"Daniel D.","family":"Callow","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nisha","family":"Rani","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Carson","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Kinesiology University of Maryland  College Park Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Soldan","sequence":"additional","affiliation":[{"name":"Department of Neurology Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinne","family":"Pettigrew","sequence":"additional","affiliation":[{"name":"Department of Neurology Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam P.","family":"Spira","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences Johns Hopkins University School of Medicine  Baltimore Maryland USA"},{"name":"Department of Mental Health Johns Hopkins Bloomberg School of Public Health  Baltimore Maryland USA"},{"name":"Johns 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