{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T17:27:06Z","timestamp":1793035626209,"version":"4.5.0"},"reference-count":75,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Postoperative delirium (POD) is common in older surgical patients and is clinically associated with an increased risk of long\u2010term cognitive decline and dementia; disrupted BDNF signaling and circadian dysregulation are implicated, but their coordinated mechanisms remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Aged male C57BL\/6J mice were exposed to anesthesia, surgery, and intensive care unit\u2010like stress (ASI). Hippocampal neuroplasticity, dendritic morphology, epigenetic regulation, and circadian signaling were assessed using molecular assays, imaging, and protein\u2013protein interaction (PPI) network analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>ASI reduced brain\u2010derived neurotrophic factor (BDNF)\u2013activity\u2010regulated cytoskeleton\u2010associated protein signaling, dendritic structural complexity, and attention, with accompanying histone hypoacetylation, an increased 5\u2010methylcytosine\/5\u2010hydroxymethylcytosine ratio, and disruption of network hubs centered on BDNF and circadian regulators. Suberoylanilide hydroxamic acid mitigated these effects and improved short\u2010term cognitive performance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Perioperative stress is associated with an epigenetically repressed, synaptically impaired hippocampal state linked to delirium\u2010like behavior and cognitive vulnerability. Targeting chromatin accessibility and BDNF\u2013circadian coupling with histone deacetylase inhibition may mitigate acute cognitive consequences following surgery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71556","type":"journal-article","created":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T03:07:56Z","timestamp":1781579276000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Epigenetically driven impairment of BDNF\u2013ARC signaling contributes to circadian and cognitive disarray in a mouse model of postoperative delirium"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3741-7048","authenticated-orcid":false,"given":"Hari Prasad","family":"Osuru","sequence":"first","affiliation":[{"name":"Department of Anesthesiology University of Virginia Health  Charlottesville 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