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ASE variants were also found in exons of known AD\u2010associated genes, including apolipoprotein E\n                      <jats:italic>(APOE)<\/jats:italic>\n                      ,\n                      <jats:italic>CLU<\/jats:italic>\n                      ,\n                      <jats:italic>CTSB<\/jats:italic>\n                      , and\n                      <jats:italic>HLA\u2010DRB1<\/jats:italic>\n                      . Forty variants exhibited AD\u2010associated ASE, and the affected genes, including\n                      <jats:italic>SLC12A5, SYT13, and TOMM7<\/jats:italic>\n                      , were predominantly downregulated in multiple cell types, including astrocytes, excitatory neurons, and oligodendrocytes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>We provided a detailed landscape of ASE in AD, uncovering novel functional variants and highlighting their potential cell\u2010type\u2013specific contributions to disease pathogenesis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71558","type":"journal-article","created":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T09:42:51Z","timestamp":1781170971000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Allele specific expression in Alzheimer's disease"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5980-4711","authenticated-orcid":false,"given":"Zishan","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Genetics and Genomic Sciences, Center for Transformative Disease Modeling, Tisch Cancer Institute, Icahn Institute for Data Science and Genomic Technology Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delowar","family":"Hossain","sequence":"additional","affiliation":[{"name":"Division of Experimental Medicine McGill University  Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judy Jiaru","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Arts and Sciences Cornell University  Ithaca New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Varun R.","family":"Subramaniam","sequence":"additional","affiliation":[{"name":"Department of Genetics and Genomic Sciences, Center for Transformative Disease Modeling, Tisch Cancer Institute, Icahn Institute for Data Science and Genomic Technology Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Genetics and Genomic Sciences, Center for Transformative Disease Modeling, Tisch Cancer Institute, Icahn Institute for Data Science and Genomic Technology Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minghui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Genetics and Genomic Sciences, Center for Transformative Disease Modeling, Tisch Cancer Institute, Icahn Institute for Data Science and Genomic Technology Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuan\u2010lin","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Genetics and Genomic Sciences, Center for Transformative Disease Modeling, Tisch Cancer Institute, Icahn Institute for Data Science and Genomic Technology Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,11]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(16)00062\u20104"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(18)30499\u2010X"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2018.02.007"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/d41573\u2010024\u201000116\u20101"},{"key":"e_1_2_11_6_1","volume-title":"U.S. 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