{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T16:57:24Z","timestamp":1793379444626,"version":"4.5.0"},"reference-count":54,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T00:00:00Z","timestamp":1783987200000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100008599","name":"Alzheimerfonden","doi-asserted-by":"publisher","award":["AF\u20101030022"],"award-info":[{"award-number":["AF\u20101030022"]}],"id":[{"id":"10.13039\/501100008599","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009741","name":"David och Astrid Hagel\u00e9ns Stiftelse","doi-asserted-by":"publisher","award":["2025\u201002544"],"award-info":[{"award-number":["2025\u201002544"]}],"id":[{"id":"10.13039\/501100009741","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021594","name":"Demensfonden","doi-asserted-by":"publisher","award":["DF\u20101031285"],"award-info":[{"award-number":["DF\u20101031285"]}],"id":[{"id":"10.13039\/501100021594","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010771","name":"Loo och Hans Ostermans Stiftelse f\u00f6r Medicinsk Forskning","doi-asserted-by":"publisher","award":["2025\u20101809"],"award-info":[{"award-number":["2025\u20101809"]}],"id":[{"id":"10.13039\/100010771","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010815","name":"Stiftelsen f\u00f6r Gamla Tj\u00e4narinnor","doi-asserted-by":"publisher","award":["2025\u2010303"],"award-info":[{"award-number":["2025\u2010303"]}],"id":[{"id":"10.13039\/100010815","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Metabolic syndrome (MetS) is associated with increased dementia risk, but its relationship with brain aging is unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>The study included 27,375 UK Biobank participants aged 40 to 70 years. MetS was defined as having at least three of five components: central adiposity, hypertension, dyslipidemia, hypertriglyceridemia, and hyperglycemia. Levels of 33 plasma metabolites were measured from baseline blood samples. Brain age was estimated using a machine learning model based on 1079 phenotypes from brain magnetic resonance imaging (MRI) scans and used to calculate brain age gap (BAG, i.e., brain age minus chronological age).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Participants with MetS had significantly higher BAG compared to MetS\u2010free individuals (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      = 1.13; 95% confidence interval [CI]: 0.99 to 1.27). Each individual MetS component was also associated with higher BAG. Eight metabolites significantly mediated the MetS\u2013BAG association (mediation proportion: 2.6% to 16.5%), including apolipoproteins, fatty acids, and inflammatory markers.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>MetS is associated with accelerated brain aging, partly mediated by inflammation and altered lipid metabolism.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71563","type":"journal-article","created":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T11:01:06Z","timestamp":1784026866000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Metabolic syndrome is associated with accelerated brain aging"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6890-0537","authenticated-orcid":false,"given":"Abigail","family":"Dove","sequence":"first","affiliation":[{"name":"Aging Research Center Department of Neurobiology Care Sciences and Society Karolinska Institutet  Stockholm Sweden"},{"name":"Division of Clinical Geriatrics Department of Neurobiology Care Sciences and Society Karolinska Institutet  Stockholm Sweden"},{"name":"Department of Neurology University of Pennsylvania Perelman School of Medicine  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiao","family":"Wang","sequence":"additional","affiliation":[{"name":"Aging Research Center Department of Neurobiology Care Sciences and Society Karolinska Institutet  Stockholm Sweden"},{"name":"National Clinical Research Center for Geriatrics West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongrong","family":"Yang","sequence":"additional","affiliation":[{"name":"Aging Research Center Department of Neurobiology Care Sciences and Society Karolinska Institutet  Stockholm Sweden"},{"name":"Public Health Science and Engineering College Tianjin University of Traditional Chinese Medicine  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sakura","family":"Sakakibara","sequence":"additional","affiliation":[{"name":"Aging Research Center Department of Neurobiology Care Sciences and Society Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoe","family":"Arvanitakis","sequence":"additional","affiliation":[{"name":"Rush Alzheimer's Disease Center Rush University Medical Center  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea L. C.","family":"Schneider","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Pennsylvania Perelman School of Medicine  Philadelphia Pennsylvania USA"},{"name":"Department of Biostatistics Epidemiology, and Informatics University of Pennsylvania Perelman School of Medicine  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca F.","family":"Gottesman","sequence":"additional","affiliation":[{"name":"National Institute of Neurological Disorders and Stroke Intramural Research Program National Institutes of Health  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weili","family":"Xu","sequence":"additional","affiliation":[{"name":"Aging Research Center Department of Neurobiology Care Sciences and Society Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/S41572\u2010024\u201000563\u20105"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.112.252759"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/CLINEM\/DGAA067"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000012415"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.106.480004"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.2337\/DC22\u20100206"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.NUMECD.2021.03.020"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ALZ.13439"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004572"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/S12883\u2010024\u201003820\u2010Y"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PMED.1002640"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000214033"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JCMG.2014.06.014"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.2337\/DC24\u20100537\/773314\/DC240537"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/FNINS.2022.942743"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.121.022107"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.2337\/DC10\u20100851"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.NEUROBIOLAGING.2020.09.023"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380\u2010018\u20100098\u20101"},{"key":"e_1_2_10_21_1","doi-asserted-by":"crossref","unstructured":"FrankeK GaserC ManorB et\u00a0al.Advanced brainage in older adults with type 2 diabetes mellitus2013;5:90. doi:10.3389\/fnagi.2013.00090","DOI":"10.3389\/fnagi.2013.00090"},{"key":"e_1_2_10_22_1","doi-asserted-by":"crossref","unstructured":"JhaMK FattCRC MinhajuddinA MayesTL BerryJD TrivediMH.Accelerated brain aging in individuals with diabetes: association with poor glycemic control and increased all\u2010cause mortality2022;145:105921. doi:10.1016\/j.psyneuen.2022.105921","DOI":"10.1016\/j.psyneuen.2022.105921"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11357\u2010024\u201001112\u20104"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/S13195\u2010023\u201001215\u20108"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.NEUROBIOLAGING.2020.03.014"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/S41598\u2010020\u201076518\u2010Z"},{"key":"e_1_2_10_27_1","doi-asserted-by":"crossref","unstructured":"SoneD BeheshtiI ShinagawaS et\u00a0al.Neuroimaging\u2010derived brain age is associated with life satisfaction in cognitively unimpaired elderly: A community\u2010based study.Transl Psychiatry.2022;12(1):25. doi:10.1038\/s41398\u2010022\u201001793\u20105","DOI":"10.1038\/s41398-022-01793-5"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.2337\/DC24\u20100860"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/ALZ.12725"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2020.105059"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.06.029"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010019\u201056909\u20107"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PMED.1001779"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.192644"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/S41398\u2010023\u201002515\u20101"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4393"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.NEUROIMAGE.2017.10.034"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000209530"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.14283\/JPAD.2024.76"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2025.105941"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654\u2010025\u201001318\u20106"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/S41467\u2010023\u201036231\u20107"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0047279400020341"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2017.153"},{"key":"e_1_2_10_45_1","unstructured":"The IPAQ Group.Guidelines for Data Processing and Analysis of the International Physical Activity Questionnaire 2005. Accessed January 10 2023.https:\/\/sites.google.com\/site\/theipaq\/scoring\u2010protocol"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PONE.0307270"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569\u2010024\u201001111\u20100"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1001\/JAMACARDIO.2021.5083"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3820"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/NATURE05485;KWRD=SCIENCE"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.3389\/FNCEL.2015.00028"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(15)70016\u20105"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwx246"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1136\/BMJ.M131"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010020\u201015948\u20109"}],"container-title":["Alzheimer's &amp; Dementia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.71563","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/alz.71563","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.71563","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T16:58:06Z","timestamp":1793206686000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz.71563"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":54,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/alz.71563"],"URL":"https:\/\/doi.org\/10.1002\/alz.71563","archive":["Portico"],"relation":{},"ISSN":["1552-5260","1552-5279"],"issn-type":[{"value":"1552-5260","type":"print"},{"value":"1552-5279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"2025-12-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71563"}}