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Logistic and linear regression models stratified by self\u2010reported race\/ethnicity were used to assess the associations of CRS with endophenotypes and CI and to evaluate predictive performance.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      CogDRisk showed the strongest and most consistent performance across endophenotypes, pTau\n                      <jats:sub>217<\/jats:sub>\n                      \/A\u03b2\n                      <jats:sub>42<\/jats:sub>\n                      positivity, and CI, with mCAIDE performing the worst and lacking associations with plasma biomarkers. Higher CRS were consistently associated with increased odds of dementia across all races\/ethnicities.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>CRSs capture AD\u2010related risk across diverse populations and modestly reflect underlying biological endophenotypes, supporting their utility in community\u2010based risk assessment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71567","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T03:50:07Z","timestamp":1785297007000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Associations of dementia polyexposure scores to Alzheimer's disease endophenotypes in a diverse population"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0487-3031","authenticated-orcid":false,"given":"Meri","family":"Okorie","sequence":"first","affiliation":[{"name":"Edward and Pearl Fein Memory and Aging Center University of California, San Francisco  San Francisco California USA"},{"name":"Department of Psychiatry and Behavioural Sciences University of California, San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaqing","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioural Sciences University of California, San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristine","family":"Yaffe","sequence":"additional","affiliation":[{"name":"Edward and Pearl Fein Memory and Aging Center University of California, San Francisco  San Francisco California USA"},{"name":"Department of Psychiatry and Behavioural Sciences University of California, San Francisco  San Francisco California USA"},{"name":"Department of Neurology and Weill Institute for Neurosciences University of California, San Francisco  San Francisco California USA"},{"name":"Department of Epidemiology and Biostatistics University of California, San Francisco  San Francisco California USA"},{"name":"San Francisco Veterans Affairs Health Care System  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7274-2634","authenticated-orcid":false,"given":"Jennifer S.","family":"Yokoyama","sequence":"additional","affiliation":[{"name":"Edward and Pearl Fein Memory and Aging Center University of California, San Francisco  San Francisco California USA"},{"name":"Department of Neurology and Weill Institute for Neurosciences University of California, San Francisco  San Francisco California USA"},{"name":"Department of Radiology and Biomedical 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