{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T15:35:47Z","timestamp":1784734547404,"version":"3.55.0"},"reference-count":83,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T00:00:00Z","timestamp":1780790400000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["CIHR PJT191806"],"award-info":[{"award-number":["CIHR PJT191806"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NIH R01AG084681"],"award-info":[{"award-number":["NIH R01AG084681"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp; Dementia"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>While Alzheimer's disease (AD) typically elicits progressive cognitive decline, some individuals with significant AD pathology maintain cognition. Understanding the neuronal underpinnings of such cognitive resilience would propel the development of interventions for delaying dementia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      We used Barnes Maze testing to identify\u00a0cognitively resilient 13\u2010month\u2010old TgF344\u2010AD rats (established AD) and their non\u2010transgenic littermates, followed by Neuropixels recording from 8500 neurons during repeated somatosensory stimulation, and culminating in\n                      <jats:italic>post mortem<\/jats:italic>\n                      tau and amyloid load quantifications.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Cognitively resilient TgF344\u2010AD rats recruited fewer neurons and displayed more stable neuronal representations during repeated stimulations in cortical excitatory and hippocampal inhibitory ensembles, with reduced excitatory spike burstiness and a distinct pattern of functional synaptic connectivity. These associations existed independently of amyloid levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>For the first time, our study revealed neuronal population\u2010level hallmarks of maintained cognition that may serve as a novel neurophysiological biomarker of cognitive resilience and a target for stabilizing cognition.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71570","type":"journal-article","created":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T03:41:53Z","timestamp":1780890113000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Stable neuronal representations underlie cognitive resilience to Alzheimer's disease pathology"],"prefix":"10.1002","volume":"22","author":[{"given":"Keying","family":"Chen","sequence":"first","affiliation":[{"name":"Physical Sciences Sunnybrook Research Institute  Toronto Ontario Canada"},{"name":"Hurvitz Brain Sciences Sunnybrook Health Sciences Centre  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Pineau","sequence":"additional","affiliation":[{"name":"Physical Sciences Sunnybrook Research Institute  Toronto Ontario Canada"},{"name":"Hurvitz Brain Sciences Sunnybrook Health Sciences Centre  Toronto Ontario Canada"},{"name":"Department of Medical Biophysics University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Koletar","sequence":"additional","affiliation":[{"name":"Physical Sciences Sunnybrook Research Institute  Toronto Ontario Canada"},{"name":"Hurvitz Brain Sciences Sunnybrook Health Sciences Centre  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Trevisiol","sequence":"additional","affiliation":[{"name":"Physical Sciences Sunnybrook Research Institute  Toronto Ontario Canada"},{"name":"Hurvitz Brain Sciences Sunnybrook Health Sciences Centre  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack Simiao","family":"He","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences McMaster University  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Hill","sequence":"additional","affiliation":[{"name":"Hurvitz Brain Sciences Sunnybrook Health Sciences Centre  Toronto Ontario Canada"},{"name":"Biological Sciences Sunnybrook Research Institute  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maged","family":"Goubran","sequence":"additional","affiliation":[{"name":"Physical Sciences Sunnybrook Research Institute  Toronto Ontario Canada"},{"name":"Hurvitz Brain Sciences Sunnybrook Health Sciences Centre  Toronto Ontario Canada"},{"name":"Department of Medical Biophysics University of Toronto  Toronto Ontario Canada"},{"name":"Harquail Centre for Neuromodulation Sunnybrook Health Sciences Centre  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Sled","sequence":"additional","affiliation":[{"name":"Department of Medical Biophysics University of Toronto  Toronto Ontario Canada"},{"name":"Mouse Imaging Centre The Hospital for Sick Children  Toronto Ontario Canada"},{"name":"Translational Medicine SickKids Research Institute  Toronto Ontario Canada"},{"name":"Department of Obstetrics &amp; Gynecology University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JoAnne","family":"McLaurin","sequence":"additional","affiliation":[{"name":"Hurvitz Brain Sciences Sunnybrook Health Sciences Centre  Toronto Ontario Canada"},{"name":"Biological Sciences Sunnybrook Research Institute  Toronto Ontario Canada"},{"name":"Department of Laboratory Medicine and Pathobiology Temerty Faculty of Medicine University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bojana","family":"Stefanovic","sequence":"additional","affiliation":[{"name":"Physical Sciences Sunnybrook Research Institute  Toronto Ontario Canada"},{"name":"Hurvitz Brain Sciences Sunnybrook Health Sciences Centre  Toronto Ontario Canada"},{"name":"Department of Medical Biophysics University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024\u2010019\u20100333\u20105"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a006189"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0b013e31825018f7"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582\u2010022\u201000642\u20109"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.65.11.1509"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.22828"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2022.02.005"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2019.101002"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-024-00719-7"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports\u20102021\u2010104981"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.54285"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916\u2010023\u201002772\u20103"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2023.3599"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13844"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(24)01296\u20100"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awab112"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201053360\u20109"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.064560"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593\u2010024\u201001688\u20102"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.adk4858"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2025.06.031"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024\u2010025\u201000892\u20103"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2023.08.039"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593\u2010020\u201000764\u20107"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201042721\u20105"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(12)70191\u20106"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2009.03.004"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3329"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0350\u201004.2004"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.46926"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2015.01.002"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1888"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1954\u201022.2023"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2023.12.008"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750\u20101326\u20108\u201037"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3672\u201012.2013"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.70708"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41592\u2010024\u201002232\u20107"},{"key":"e_1_2_8_40_1","first-page":"22095","article-title":"Three\u2010dimensional spike localization and improved motion correction for Neuropixels recordings","volume":"34","author":"Boussard J","year":"2021","journal-title":"NeurIPS"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2018.12.009"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1000433"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.3389\/fdgth.2021.758031"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.072101"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429\u2010017\u20101489\u20109"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.490390607"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2019.5154"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awad100"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07991"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08002"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010neuro\u2010062111\u2010150444"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896\u20106273(02)00586\u2010X"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5665\u201008.2009"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00845.2002"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.52108"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41539\u2010016\u20100001\u20102"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010024\u201001911\u20103"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.14283\/jpad.2024.122"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10571\u2010017\u20100574\u20101"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40035\u2010025\u201000465\u2010w"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673\u20105374.340409"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010025\u201001775\u2010x"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0914886107"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.3390\/cimb46030130"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2017.00298"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398\u2010022\u201002024\u20107"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2621"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.10.008"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380\u2010023\u201002168\u2010y"},{"key":"e_1_2_8_70_1","article-title":"Biophysical Kv3 channel alterations dampen excitability of cortical PV interneurons and contribute to network hyperexcitability in early","volume":"11","author":"Olah VJ","year":"2022","journal-title":"Alzheimer's eLife"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.08.034"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40035\u2010022\u201000300\u20106"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncir.2021.687558"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.11.6448"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1782"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2015.00191"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12915\u2010019\u20100732\u20107"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429\u2010020\u201002044\u20103"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010200527"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.02.046"},{"key":"e_1_2_8_81_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0425\u201020.2020"},{"key":"e_1_2_8_82_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.23650"},{"key":"e_1_2_8_83_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000467"},{"key":"e_1_2_8_84_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13355"}],"container-title":["Alzheimer's &amp; Dementia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.71570","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/alz.71570","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.71570","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T10:09:35Z","timestamp":1783246175000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz.71570"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":83,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1002\/alz.71570"],"URL":"https:\/\/doi.org\/10.1002\/alz.71570","archive":["Portico"],"relation":{},"ISSN":["1552-5260","1552-5279"],"issn-type":[{"value":"1552-5260","type":"print"},{"value":"1552-5279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"2026-01-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71570"}}