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Amyloid beta (A\u03b2) positivity was defined using PET or plasma.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Tau\u2010PET showed an anterior\u2013posterior gradient, with highest uptake in BA35, ERC, and anterior hippocampus. Increased MTL tau\u2010PET uptake and plasma p\u2010tau217 were associated with cortical thinning localized to BA35 and ERC, even in cognitively unimpaired A\u03b2\u2010positive individuals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>Anterior MTL subregions, especially BA35, show early vulnerability to tau\u2010related neurodegeneration. Extended anterior MTL parcellation improves localization of early tau\u2010associated structural changes and may facilitate biological staging in preclinical AD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71571","type":"journal-article","created":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T02:48:16Z","timestamp":1781750896000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Vulnerability of anterior medial temporal lobe subregions to early tau\u2010related neurodegeneration in Alzheimer's disease: Converging evidence from tau\u2010PET and plasma p\u2010tau217"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3108-6751","authenticated-orcid":false,"given":"Nidhi S.","family":"Mundada","sequence":"first","affiliation":[{"name":"Department of Bioengineering University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niyousha","family":"Sadeghpour","sequence":"additional","affiliation":[{"name":"Department of Radiology Perelman School of Medicine at the University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"McGrew","sequence":"additional","affiliation":[{"name":"Department of Neurology Perelman School of Medicine at the University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah L.","family":"Tucker","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund Lund University  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilya M","family":"Nasrallah","sequence":"additional","affiliation":[{"name":"Department of Radiology Perelman School of Medicine at the University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandhitsu R.","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Neurology Perelman School of Medicine at the University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Wolk","sequence":"additional","affiliation":[{"name":"Department of Neurology Perelman School of Medicine at the University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul A.","family":"Yushkevich","sequence":"additional","affiliation":[{"name":"Department of Radiology Perelman School of Medicine at the University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher A","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Neurology Perelman School of Medicine at the University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura E. 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