{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T04:45:12Z","timestamp":1789620312625,"version":"build-2803163510"},"reference-count":56,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100004331","name":"Johnson and Johnson","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004331","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Inhibition of pathological tau spread may slow cognitive decline in Alzheimer's disease. Here, we evaluate two tau positron emission tomography (PET) analysis methods designed for detecting tau spread.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Spatial progression of tauopathy (SPOT) and tau\u2010na\u00efve anatomical region of interest (tau\u2010na\u00efve ROI) methods were assessed in two large observational cohorts in amyloid\u2010positive (A+) cognitively unimpaired (CU) or mildly cognitively impaired (MCI) participants versus CU amyloid\u2010negative (A\u2212) participants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>SPOT and tau\u2010na\u00efve ROI demonstrated measurable annualized change in CU A+ and MCI A+ participants versus CU A\u2212 participants. These spread estimates produced effect sizes comparable to standardized uptake value ratio (SUVR) change measures in anatomically defined ROIs. Effect sizes were increased when evaluating the subset of tau positive CU A+ and MCI A+ participants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>SPOT and tau\u2010na\u00efve ROI methods are designed to measure tau spread and may be used in addition to traditional SUVR measures to evaluate tau progression in AD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71573","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T03:35:46Z","timestamp":1782272146000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Tau positron emission tomography analysis methods for the quantification of tau spread in preclinical and early Alzheimer's disease"],"prefix":"10.1002","volume":"22","author":[{"given":"Janice","family":"Wong","sequence":"first","affiliation":[{"name":"Johnson &amp; Johnson  Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina","family":"Wang","sequence":"additional","affiliation":[{"name":"Johnson &amp; Johnson  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritobrato","family":"Datta","sequence":"additional","affiliation":[{"name":"Johnson &amp; Johnson  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rouhollah O.","family":"Abdollahi","sequence":"additional","affiliation":[{"name":"Johnson &amp; Johnson  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingwei","family":"Li","sequence":"additional","affiliation":[{"name":"Johnson &amp; Johnson  Neuss Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher C","family":"Rowe","sequence":"additional","affiliation":[{"name":"Department of Molecular Imaging &amp; Therapy Austin Health  Heidelberg Victoria Australia"},{"name":"The Florey Institute of Neuroscience and Mental Health The University of Melbourne  Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Henley","sequence":"additional","affiliation":[{"name":"Johnson &amp; 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