{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T09:11:56Z","timestamp":1789204316573,"version":"build-2803163510"},"reference-count":47,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Healthy aging reflects the maintenance of intrinsic capacity (IC) across five physical and mental domains. Although IC decline has been linked to frailty and mortality, evidence regarding its predictive value for dementia remains limited, particularly in low\u2010 and middle\u2010income countries.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Data from 7263 adults aged \u226560 years without baseline dementia from the Mexican Health and Aging Study (2012\u20132015) were analyzed. IC was assessed across vitality, locomotor, sensory, cognitive, and psychological domains. Dementia was defined as impairment in two or more cognitive domains plus one or more limitation in instrumental activities of daily living.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>The mean age of the study population was 68.92\u00a0\u00b1\u00a06.8 years and 55.4% were women. Dementia incidence over 3 years was 4.15%. Higher baseline IC scores were associated with lower odds of incident dementia (adjusted odds ratio [OR]\u00a0=\u00a00.62; 95% confidence interval [CI]: 0.41\u20130.94).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Our findings support the role of IC as an early, multidimensional marker of cognitive vulnerability.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71578","type":"journal-article","created":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T02:49:43Z","timestamp":1781750983000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association between intrinsic capacity and dementia risk in older Mexicans"],"prefix":"10.1002","volume":"22","author":[{"given":"Miriam Teresa","family":"L\u00f3pez\u2010Teros","sequence":"first","affiliation":[{"name":"Department of Nutrition Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara Gabriela","family":"Yeverino\u2010Castro","sequence":"additional","affiliation":[{"name":"Geriatrics Service Universidad Aut\u00f3noma de Nuevo Le\u00f3n Dr. Jos\u00e9 E. Gonz\u00e1lez University Hospital Monterrey Nuevo Le\u00f3n M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiola","family":"Yocupicio\u2010 Medrano","sequence":"additional","affiliation":[{"name":"Department of Nutrition Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto Jos\u00e9","family":"Mimenza\u2010Alvarado","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n  Tlalpan, Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis Miguel","family":"Guti\u00e9rrez\u2010Robledo","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Instituto Nacional de Geriatr\u00eda  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar Yaxmehen","family":"Bello\u2010Chavolla","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Instituto Nacional de Geriatr\u00eda  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2323-7644","authenticated-orcid":false,"given":"Sara Gloria","family":"Aguilar\u2010Navarro","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n  Tlalpan, Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/dad2.12237"},{"key":"e_1_2_8_3_1","unstructured":"World Health Organization.Dementia.2025[cited Nov 3 2025].https:\/\/www.who.int\/news\u2010room\/fact\u2010sheets\/detail\/dementia"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2012.11.007"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010191092"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/0898264311421199"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000209452"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.14283\/jfa.2024.30"},{"key":"e_1_2_8_9_1","unstructured":"World Health Organization.Integrated care for older people approach (ICOPE) [Internet].2025[cited 2025 Nov 3].https:\/\/www.who.int\/teams\/maternal\u2010newborn\u2010child\u2010adolescent\u2010health\u2010and\u2010ageing\/ageing\u2010and\u2010health\/integrated\u2010care\u2010for\u2010older\u2010people\u2010icope"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12877\u2010022\u201002980\u20101"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102018\u2010026119"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12603\u2010021\u20101629\u2010z"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010025\u201092271\u20107"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glab279"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afae162"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archger.2024.105335"},{"key":"e_1_2_8_17_1","doi-asserted-by":"crossref","unstructured":"Cite DibelloV QuartoS CavalcantiR CustoderoC ChiapparinoC LozuponeM et\u00a0al.Association between periodontal disease and intrinsic capacity in older adults: insights from NHANES 2009\u20102014.Geroscience. 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