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Self\u2010reported SB was assessed at visit 1 (1987\u20131989), with neuroimaging (3T magnetic resonance imaging [MRI]) at visit 5 (2011\u20132013). Participants were non\u2010demented adults (57% women; 53[5.2] years) who reported frequency of TV watching and occupational sitting. Outcomes included cortical, subcortical, and Alzheimer's disease\u2013signature regions (ADSR), and total WMH brain volumes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Frequent TV watching was associated with increased WMH volume and reduced frontal, occipital, and ADSR volumes. Sitting during work, which is more cognitively active, was linked to lower WMH and larger frontal (males only), occipital, and parietal volumes. Results remained consistent when adjusted for physical activity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>SB is associated with structural brain and WMH volumes. Cognitively active SB may preserve brain structure and cerebrovascular health.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71582","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T11:00:56Z","timestamp":1783681256000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Associations of distinct sedentary behaviors with cortical, subcortical, and white matter hyperintensity volumes: Evidence from the ARIC study"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6295-9792","authenticated-orcid":false,"given":"Natan","family":"Feter","sequence":"first","affiliation":[{"name":"Human and Evolutionary Biology Section, Department of Biological Sciences University of Southern California  California USA"},{"name":"Postgraduate Program of Epidemiology, School of Medicine Universidade Federal do Rio Grande do Sul  Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anamika","family":"Nanda","sequence":"additional","affiliation":[{"name":"Human and Evolutionary Biology Section, Department of Biological Sciences University of Southern California  California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Hourihan","sequence":"additional","affiliation":[{"name":"Human and Evolutionary Biology Section, Department of Biological Sciences University of Southern California  California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Aslan","sequence":"additional","affiliation":[{"name":"Department of Human Evolutionary Biology Harvard University  Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayne","family":"Feter","sequence":"additional","affiliation":[{"name":"Postgraduate Program of Epidemiology, School of Medicine Universidade Federal do Rio Grande do Sul  Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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