{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T14:48:09Z","timestamp":1782312489062,"version":"3.54.5"},"reference-count":53,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:00:00Z","timestamp":1781136000000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["SG\u201020\u2010678486\u2010GAAIN2"],"award-info":[{"award-number":["SG\u201020\u2010678486\u2010GAAIN2"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>\n                      Weak associations of apolipoprotein E (\n                      <jats:italic>APOE<\/jats:italic>\n                      ) \u03b54 with cognitive impairment have been reported in Hispanic cohorts. To determine if\n                      <jats:italic>APOE<\/jats:italic>\n                      \u03b54 associates with brain amyloid load differently in Hispanic and non\u2010Hispanic White (NHW) cohorts, we analyzed reported Centiloid values from studies that conducted amyloid positron emission tomography.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>This meta\u2010analysis included 17,017 participants (8.4% Hispanic) from five source studies. Analysis of covariance and logistic regression models adjusting for age, sex, education, and cognitive score were applied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Although cognitive impairment and\n                      <jats:italic>APOE<\/jats:italic>\n                      \u03b54 were associated with higher Centiloids in both Hispanic and NHW cohorts, cognitively impaired and\n                      <jats:italic>APOE<\/jats:italic>\n                      \u03b54 positive Hispanic participants had lower Centiloids than NHW participants with the same conditions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>\n                      <jats:italic>APOE<\/jats:italic>\n                      \u03b54 may have a weaker influence on brain amyloid load in Hispanic cohorts. Further comparative analyses are necessary for Alzheimer's disease anti\u2010amyloid treatments to be widely applicable to Hispanic populations.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71586","type":"journal-article","created":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T09:44:30Z","timestamp":1781171070000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of cognitive impairment and\n                    <i>APOE<\/i>\n                    \u03b54 with Centiloids in Hispanic and non\u2010Hispanic White cohorts"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7172-3175","authenticated-orcid":false,"given":"Cally","family":"Xiao","sequence":"first","affiliation":[{"name":"Laboratory of Neuro Imaging USC Stevens Neuroimaging and Informatics Institute Keck School of Medicine of USC University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tyler","family":"Ard","sequence":"additional","affiliation":[{"name":"Laboratory of Neuro Imaging USC Stevens Neuroimaging and Informatics Institute Keck School of Medicine of USC University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ganna","family":"Blazhenets","sequence":"additional","affiliation":[{"name":"Edward and Pearl Fein Memory and Aging Center Department of Neurology Weill Institute for Neurosciences University of California San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renaud","family":"La Joie","sequence":"additional","affiliation":[{"name":"Edward and Pearl Fein Memory and Aging Center Department of Neurology Weill Institute for Neurosciences University of California San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Pappas","sequence":"additional","affiliation":[{"name":"Laboratory of Neuro Imaging USC Stevens Neuroimaging and Informatics Institute Keck School of Medicine of USC University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur W.","family":"Toga","sequence":"additional","affiliation":[{"name":"Laboratory of Neuro Imaging USC Stevens Neuroimaging and Informatics Institute Keck School of Medicine of USC University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Alzheimer's Disease Neuroimaging Initiative","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Health and Aging Brain Study (HABS\u2010HD) Study Team","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2014.07.003"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14336"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.115.171595"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259\u2010017\u20103749\u20106"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13550\u2010018\u20100456\u20107"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.06.1353"},{"key":"e_1_2_9_8_1","unstructured":"Centiloid Project.The Global Alzheimer's Association Interactive Network. 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