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We examined LC\u2013entorhinal cortex (LC\u2010EC) tract integrity and its association with amyloid and tau pathology and memory in autosomal dominant AD (ADAD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      We examined associations between diffusion\u2010weighted imaging\u2010derived LC\u2010EC tract characteristics and age, sex, amyloid (Pittsburgh Compound B [PiB]), entorhinal tau ([\n                      <jats:sup>18<\/jats:sup>\n                      F]\u2010flortaucipir [\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010FTP] positron emission tomography [PET]), and memory in PSEN1\u2010E280A mutation carriers (n\u00a0=\u00a030) and non\u2010carriers (n\u00a0=\u00a033).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>LC\u2010EC tract integrity was lower in females and older individuals in both non\u2010carriers and carriers. In mutation carriers, lower tract integrity was associated with higher entorhinal tau and poorer memory, with tau and amyloid mediating the tract\u2010memory relationship in the entire sample but not in unimpaired carriers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>These findings highlight the LC\u2010EC tract as an early disease vulnerability marker in ADAD, with tract disruption associated with memory decline across disease stages, a relationship further mediated by entorhinal tau pathology as disease progresses.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71587","type":"journal-article","created":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T09:29:15Z","timestamp":1781170155000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Vulnerability of the locus coeruleus\u2013entorhinal cortex white matter tract in autosomal dominant Alzheimer's disease"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4105-4254","authenticated-orcid":false,"given":"Elouise A.","family":"Koops","sequence":"first","affiliation":[{"name":"The Athinoula A. Martinos Center for Biomedical Imaging Department of Radiology Massachusetts General Hospital, Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Averi","family":"Giudicessi","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Department of Psychological and Brain Sciences Boston University  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Baena","sequence":"additional","affiliation":[{"name":"Grupo de Neurociencias de Antioquia Universidad de Antioquia  Medell\u00edn Antioquia Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lusiana","family":"Martinez","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Department of Psychological and Brain Sciences Boston University  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikole","family":"Bonillas\u2010Felix","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randy","family":"Medrano","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joyita","family":"Dutta","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering University of Massachusetts Amherst  Amherst Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabela","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Alvarez","sequence":"additional","affiliation":[{"name":"Department of Radiology Hospital Pablo Tob\u00f3n Uribe  Medell\u00edn Antioquia Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Aguillon","sequence":"additional","affiliation":[{"name":"Grupo de Neurociencias de Antioquia Universidad de Antioquia  Medell\u00edn Antioquia Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yakeel T.","family":"Quiroz","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Department of Psychological and Brain Sciences Boston University  Boston Massachusetts USA"},{"name":"Grupo de Neurociencias de Antioquia Universidad de Antioquia  Medell\u00edn Antioquia Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi I. 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