{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T14:48:09Z","timestamp":1782312489776,"version":"3.54.5"},"reference-count":161,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder driven by intersecting pathological processes. Persistent attrition in AD drug\u2010development pipelines highlights the limited clinical impact of single\u2010target therapies and has increased interest in multi\u2010target approaches acting on shared biological hubs. Although recent strategies extend beyond amyloid\u2010centered interventions, much of the evidence supporting multifunctional compounds remains preclinical or shows heterogeneous outcomes in advanced clinical stages. This narrative review examines drug candidates that have entered Phase III clinical trials in the last decade, with emphasis on emerging multitarget pharmacotherapies such as muscarinic M1 receptor agonists, dual M1\/sigma\u20101 receptor (\u03c31R) agonists, and dual \u03c31R agonist\/anti\u2010amyloid agents. We also discuss complementary non\u2010pharmacological interventions, including physical exercise and targeted nutrition, that may support cognitive and emotional outcomes. Finally, we propose the Synergistic Optimized Pharmacological and Holistic Interventions for AD (SOPHI\u2010AD) framework as a conceptual and testable approach integrating multitarget pharmacology with lifestyle\u2010based strategies for AD management.<\/jats:p>","DOI":"10.1002\/alz.71589","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T03:37:42Z","timestamp":1782272262000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Redirecting Alzheimer's disease therapeutics: Multitarget drugs and complementary non\u2010pharmacological strategies"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7529-8476","authenticated-orcid":false,"given":"Humberto","family":"Mart\u00ednez\u2010Orozco","sequence":"first","affiliation":[{"name":"Institute of Neurobiology Campus Juriquilla National Autonomous University of Mexico  Queretaro Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas","family":"Andrade\u2010Guerrero","sequence":"additional","affiliation":[{"name":"Institute of Neurobiology Campus Juriquilla National Autonomous University of Mexico  Queretaro Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelly Jovana","family":"Past\u00e9n\u2010Castrej\u00f3n","sequence":"additional","affiliation":[{"name":"Institute of Neurobiology Campus Juriquilla National Autonomous University of Mexico  Queretaro Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chryslaine","family":"Rodr\u00edguez\u2010Tanty","sequence":"additional","affiliation":[{"name":"Department of Neurochemistry Cuban Center for Neurosciences  Havana Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3354-2717","authenticated-orcid":false,"given":"Sof\u00eda Y","family":"Diaz\u2010Miranda","sequence":"additional","affiliation":[{"name":"Institute of Neurobiology Campus Juriquilla National Autonomous University of Mexico  Queretaro Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,23]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"Organization WH.Dementia.Worldwide Health Organization;2025."},{"key":"e_1_2_11_3_1","unstructured":"Association As.Alzheimer's Disease Facts and Figures.Alzheimer's Association;2025."},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(20)32205\u20104"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24043754"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11011\u2010021\u201000814\u20104"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/procel\/pwae026"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010024\u201001911\u20103"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(20)30440\u20103"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010023\u201001314\u20106"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874609814666210302085232"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40035\u2010024\u201000432\u2010x"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2024.05.005"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/alzrt269"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddq160"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4305\u201010.2010"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010016\u20100207\u20109"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1586\/14737175.2015.995638"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.02.040"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trci.2017.05.002"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/trc2.12295"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trci.2019.05.008"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/trc2.12050"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trci.2018.03.009"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/trc2.12179"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trci.2016.07.001"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/trc2.12385"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/trc2.12465"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/trc2.70098"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201606210"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40035\u2010024\u201000397\u2010x"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aggp.2025.100207"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/trc2.70004"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/trc2.12498"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjpad.2024.100016"},{"key":"e_1_2_11_36_1","volume-title":"Athira Pharma Announces Topline Results from Phase 2\/3 LIFT\u2010AD Clinical Trial of Fosgonimeton for Mild\u2010to\u2010Moderate Alzheimer's Disease","author":"Pharma A"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.3233\/ADR\u2010200250"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6468(05)43004-0"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(03)45003-6"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.50.1.136"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn992"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749\u20106632.2000.tb06937.x"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6894649"},{"key":"e_1_2_11_44_1","volume-title":"AF64A Induced Cholinotoxicity: Gehavioral and Biochemical Correlates","author":"Brandeis R","year":"1986"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022\u20103565(25)24808\u2010X"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960\u2010894X(00)80541\u20107"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749\u20106632.1993.tb23070.x"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/1531\u20108249(200012)48:6%3c913::AID\u2010ANA12%3e3.0.CO;2\u2010S"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010150152"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091\u20103057(94)00435\u2010L"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471\u20104159.1999.0720206.x"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12031\u2010002\u20100025\u20103"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.2174\/156720509787602915"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896\u20106273(03)00434\u20103"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2006.01.020"},{"key":"e_1_2_11_56_1","unstructured":"Foundation AsDD.NSC001 (also known as AF267B NGX267 and NI004).2024."},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.705575"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.15693"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974\u2010015\u20100250\u20107"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022\u20103565(25)30536\u20107"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022\u20103565(25)33330\u20106"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022\u20103565(25)10951\u20108"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006\u20108993(94)91397\u20108"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006\u20108993(94)91398\u20106"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091\u20103057(94)90235\u20106"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006\u20108993(95)01032\u20107"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306\u20104522(97)00405\u20103"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1358\/dnp.2002.15.10.740241"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.105.097394"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0706927"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974\u2010016\u20100476\u2010z"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0707386"},{"key":"e_1_2_11_73_1","first-page":"415","article-title":"M\u00e9canisme d'action de la t\u00e9trahydro\u2010N, N\u2010dim\u00e9thyl\u20105, 5\u2010diph\u00e9nyl\u20103\u2010furanem\u00e9thanamine, un d\u00e9riv\u00e9 potentiellement nootrope, anti\u00e9pileptique et antid\u00e9presseur [Mechanism of action of tetrahydro\u2010N, N\u2010dimethyl\u20105, 5\u2010diphenyl\u20103\u2010furanemethanamine, a putative nootropic, anti\u2010epileptic and antidepressant compound]","volume":"60","author":"Vamvakid\u00e8s A","year":"2002","journal-title":"Ann Pharm Fr"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2008.212"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881110379286"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2012.01.039"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2017.11.009"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2023.09.010"},{"key":"e_1_2_11_79_1","unstructured":"Corp ALS.Anavex life sciences announces initiation of first\u2010in\u2010human phase 1 study of ANAVEX\u00ae3\u201071 (AF710B).2020."},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpdd.1303"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpdd.1323"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2022.1045616"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742\u20104658.2006.05181.x"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2022.1071168"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.1006\/nbdi.2002.0502"},{"key":"e_1_2_11_86_1","first-page":"533","article-title":"Peptide inhibitors of beta\u2010amyloid aggregation","volume":"10","author":"Doig AJ","year":"2007","journal-title":"Curr Opin Drug Discov Devel"},{"issue":"1","key":"e_1_2_11_87_1","first-page":"10","article-title":"Assembly of Alzheimer's amyloid\u2010beta fibrils and approaches for therapeutic intervention","volume":"8","author":"Yang DS","year":"2001","journal-title":"Amyloid"},{"key":"e_1_2_11_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2022.01.117"},{"key":"e_1_2_11_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2005.07.004"},{"key":"e_1_2_11_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2011.02.044"},{"key":"e_1_2_11_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2010.02.031"},{"key":"e_1_2_11_92_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874471012666190102165053"},{"key":"e_1_2_11_93_1","first-page":"1","article-title":"Identificaci\u00f3n y caracterizaci\u00f3n in silico de la zona de interaci\u00f3n entre el p\u00e9ptido beta\u2010amiloide y compuestos derivados del naftaleno","volume":"43","author":"Bencomo\u2010Mart\u00ednez A.","year":"2012","journal-title":"Revista CENIC Ciencias Qu\u00edmicas"},{"key":"e_1_2_11_94_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0135292"},{"key":"e_1_2_11_95_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23030686"},{"key":"e_1_2_11_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2020.115700"},{"key":"e_1_2_11_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2024.06.013"},{"key":"e_1_2_11_98_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26031301"},{"key":"e_1_2_11_99_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abh3763"},{"key":"e_1_2_11_100_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP279521"},{"key":"e_1_2_11_101_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4MD00630E"},{"key":"e_1_2_11_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2024.107152"},{"key":"e_1_2_11_103_1","doi-asserted-by":"publisher","DOI":"10.1002\/trc2.70050"},{"key":"e_1_2_11_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2021.101479"},{"key":"e_1_2_11_105_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13668\u2010019\u20100271\u20104"},{"key":"e_1_2_11_106_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.1574"},{"key":"e_1_2_11_107_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010024\u201001505\u20109"},{"key":"e_1_2_11_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2023.04.001"},{"key":"e_1_2_11_109_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010021\u201000922\u20104"},{"key":"e_1_2_11_110_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010240230"},{"key":"e_1_2_11_111_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11655\u2010022\u20103511\u20106"},{"key":"e_1_2_11_112_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12906\u2010023\u201003888\u2010y"},{"key":"e_1_2_11_113_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2023.1035376"},{"key":"e_1_2_11_114_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010024\u201001484\u2010x"},{"key":"e_1_2_11_115_1","doi-asserted-by":"publisher","DOI":"10.2144\/fsoa\u20102023\u20100155"},{"key":"e_1_2_11_116_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci14111064"},{"key":"e_1_2_11_117_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41377\u2010021\u201000617\u20103"},{"key":"e_1_2_11_118_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202304025"},{"key":"e_1_2_11_119_1","doi-asserted-by":"publisher","DOI":"10.1177\/13872877251313819"},{"key":"e_1_2_11_120_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398\u2010022\u201001897\u2010y"},{"key":"e_1_2_11_121_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2025.1524898"},{"key":"e_1_2_11_122_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010023\u201001214\u20109"},{"key":"e_1_2_11_123_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.5581"},{"key":"e_1_2_11_124_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010024\u201001482\u2010z"},{"key":"e_1_2_11_125_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241914686"},{"key":"e_1_2_11_126_1","article-title":"A systematic review of dietary supplements in Alzheimer's disease","volume":"15","author":"Chimakurthy AK","year":"2023","journal-title":"Cureus"},{"key":"e_1_2_11_127_1","unstructured":"Corp ALS.Anavex Life Sciences Announces Positive Topline Results from Phase 2 Study of ANAVEX\u00ae3\u201071 for the Treatment of Schizophrenia.2025."},{"key":"e_1_2_11_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2019.172796"},{"key":"e_1_2_11_129_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010021\u201094079\u20107"},{"key":"e_1_2_11_130_1","unstructured":"Corp ALS.Anavex Releases Promising Full Preclinical Epilepsy Data at Antiepileptic Drug Trials XIII Conference.2015."},{"key":"e_1_2_11_131_1","unstructured":"Corp ALS.Anavex Announces Positive Preclinical Data for ANAVEX 2\u201073 in Infantile Spasms.2016."},{"key":"e_1_2_11_132_1","unstructured":"Wire GN.Anavex Life Sciences Reports New Data for ANAVEX 2\u201073 in Neurodevelopmental Disorders Including Angelman Syndrome: Data Presented at Antiepileptic Drug Trials XIV 2017 Conference.2017."},{"key":"e_1_2_11_133_1","unstructured":"Corp ALS.Anavex Life Sciences Announces Additional Data at The Michael J. Fox Foundation's Parkinson's Disease Therapeutics Conference.2017."},{"key":"e_1_2_11_134_1","unstructured":"Corp ALS.Anavex Received Agreement from the Committee for Medicinal Products for Human Use (CHMP) for the Submission of a Marketing Authorisation Application of Oral Blarcamesine for Alzheimer's Disease.2023."},{"key":"e_1_2_11_135_1","unstructured":"Corp ALS.Anavex Life Sciences Announces Grant of U.S. Patent Covering Blarcamesine (ANAVEX\u00ae2\u201073) for Treatment of Neurodevelopmental Disorders.2024."},{"key":"e_1_2_11_136_1","unstructured":"Corp ALS. U.S.FDA Grants Orphan Drug Designation to ANAVEX 3\u201071 for the Treatment of Frontotemporal Dementia.2016."},{"key":"e_1_2_11_137_1","unstructured":"Corp ALS.Therapeutic Candidates."},{"key":"e_1_2_11_138_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpha.2022.04.001"},{"key":"e_1_2_11_139_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003\u2010022\u201004398\u20102"},{"key":"e_1_2_11_140_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2024.148848"},{"key":"e_1_2_11_141_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells12010197"},{"key":"e_1_2_11_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2025.111226"},{"key":"e_1_2_11_143_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abk1051"},{"key":"e_1_2_11_144_1","doi-asserted-by":"publisher","DOI":"10.4155\/fmc\u20102022\u20100170"},{"key":"e_1_2_11_145_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/5120230"},{"key":"e_1_2_11_146_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2025.1527242"},{"key":"e_1_2_11_147_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms231911037"},{"key":"e_1_2_11_148_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2020.101108"},{"key":"e_1_2_11_149_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells12212531"},{"key":"e_1_2_11_150_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415\u2010022\u201011454\u20108"},{"key":"e_1_2_11_151_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010018\u20100275\u20104"},{"key":"e_1_2_11_152_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2021.108744"},{"key":"e_1_2_11_153_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12877\u2010024\u201005060\u20108"},{"key":"e_1_2_11_154_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2022.120166"},{"key":"e_1_2_11_155_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13668\u2010024\u201000539\u20107"},{"key":"e_1_2_11_156_1","doi-asserted-by":"publisher","DOI":"10.1093\/advances\/nmz054"},{"key":"e_1_2_11_157_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cdnut.2023.102011"},{"key":"e_1_2_11_158_1","doi-asserted-by":"publisher","DOI":"10.1002\/trc2.70101"},{"key":"e_1_2_11_159_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.33982"},{"key":"e_1_2_11_160_1","doi-asserted-by":"publisher","DOI":"10.15167\/2421\u20104248\/jpmh2022.63.2S3.2759"},{"key":"e_1_2_11_161_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11030554"},{"key":"e_1_2_11_162_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22062897"}],"container-title":["Alzheimer's &amp; Dementia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.71589","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/alz.71589","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.71589","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T14:08:44Z","timestamp":1782310124000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz.71589"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":161,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1002\/alz.71589"],"URL":"https:\/\/doi.org\/10.1002\/alz.71589","archive":["Portico"],"relation":{},"ISSN":["1552-5260","1552-5279"],"issn-type":[{"value":"1552-5260","type":"print"},{"value":"1552-5279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"2025-12-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71589"}}