{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:49:13Z","timestamp":1787168953231,"version":"build-2736575974"},"reference-count":65,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:00:00Z","timestamp":1781049600000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>The polyunsaturated fatty acids (PUFAs) omega\u20106 (\u03c96) and omega\u20103 (\u03c93) are linked to cognitive performance and Alzheimer's\u2010type dementia (DAT), but \u03c93\u2010PUFA supplementation offers limited benefits. We propose that the \u03c96\u2010PUFA\/\u03c93\u2010PUFA ratio better explains cognitive decline and DAT risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      PUFA profiles were examined in the AgeCoDe cohort (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a03327) and MAPT trial (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a01679). Cox and linear mixed models evaluated associations of individual PUFAs and the \u03c96\u2010PUFA\/\u03c93\u2010PUFA ratio with DAT progression and cognitive decline. Mendelian randomization (MR) assessed genetic causal effects. The effect of \u03c93\u2010PUFA on \u03c96\u2010PUFA levels was analyzed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Higher \u03c96\u2010PUFA\/\u03c93\u2010PUFA ratio increased DAT risk beyond \u03c93\u2010PUFA levels alone. A baseline high (detrimental) ratio predicted faster cognitive decline, whereas longitudinal improvements slowed decline. MR supported a genetic non\u2010causal link. Higher \u03c93\u2010PUFA levels correlated with lower \u03c96\u2010PUFA species.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>The \u03c96\u2010PUFA\/\u03c93\u2010PUFA ratio better predicts cognitive decline and DAT progression than individual PUFAs, suggesting that dietary adjustments may help prevent dementia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71590","type":"journal-article","created":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T03:41:06Z","timestamp":1781149266000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Prediction of cognitive outcome and progression to dementia using \u03c96\u2010PUFA\/\u03c93\u2010PUFA ratio"],"prefix":"10.1002","volume":"22","author":[{"given":"V\u00edctor","family":"Andrade","sequence":"first","affiliation":[{"name":"Division of Neurogenetics and Molecular Psychiatry Department of Psychiatry and Psychotherapy Medical faculty University of Cologne  Cologne Germany"},{"name":"Department of Cognitive Disorders and Old Age Psychiatry University Hospital Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Kleineidam","sequence":"additional","affiliation":[{"name":"Department of Cognitive Disorders and Old Age Psychiatry University Hospital Bonn  Bonn Germany"},{"name":"German Center for Neurodegenerative Diseases (DZNE)  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger","family":"Wagner\u2010Thelen","sequence":"additional","affiliation":[{"name":"Division of Neurogenetics and Molecular Psychiatry Department of Psychiatry and Psychotherapy Medical faculty University of Cologne  Cologne 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